Synthesis, Characterization and Application of a MIP-polyHIPE for Selective Extraction of Angiotensin II Receptor Antagonists Residues in Natural Waters

Andrea Speltini (), Giancarla Alberti, Riccardo Rovida, Chiara Milanese, Giulia De Soricellis, Francesca Rinaldi, Gabriella Massolini, Angelo Gallo and Enrica Calleri ()
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Andrea Speltini: Department of Chemistry, University of Pavia, via Taramelli 12, 27100 Pavia, Italy
Giancarla Alberti: Department of Chemistry, University of Pavia, via Taramelli 12, 27100 Pavia, Italy
Riccardo Rovida: Department of Chemistry, University of Pavia, via Taramelli 12, 27100 Pavia, Italy
Chiara Milanese: Department of Chemistry, University of Pavia, via Taramelli 12, 27100 Pavia, Italy
Giulia De Soricellis: Department of Drug Sciences, University of Pavia, via Taramelli 12, 27100 Pavia, Italy
Francesca Rinaldi: Department of Drug Sciences, University of Pavia, via Taramelli 12, 27100 Pavia, Italy
Gabriella Massolini: Department of Drug Sciences, University of Pavia, via Taramelli 12, 27100 Pavia, Italy
Angelo Gallo: Department of Chemistry, University of Turin, via Pietro Giuria 7, 10125 Turin, Italy
Enrica Calleri: Department of Drug Sciences, University of Pavia, via Taramelli 12, 27100 Pavia, Italy

IJERPH, 2023, vol. 20, issue 6, 1-15

Abstract: Polymers via high internal phase emulsion (polyHIPEs) were molecularly imprinted with Irbesartan, an antihypertensive drug belonging to the class of angiotensin II receptor antagonists (sartan drugs), chosen for the proof-of-concept extraction of hazardous emerging contaminants from water. Different analyte-functional monomer molar ratios (1:100, 1:30 and 1:15) were investigated, and the MIP polyHIPEs have been characterized, parallel to the not imprinted polymer (NIP), by batch sorption experiments. The material with the highest template-functional monomer ratio was the best for Irbesartan removal, showing a sorption capacity fivefold higher than the NIP. Regarding the adsorption kinetics, the analyte–sorbent equilibrium was reached after about 3 h, and the film diffusion model best fitted the kinetic profile. Selectivity was further demonstrated by testing Losartan, another sartan drug, observing a fourfold lower sorption capacity, but still higher than that of NIP. The polymers were also synthesized in cartridges for solid-phase extraction (SPE), which was helpful for evaluating the breakthrough curves and performing pre-concentrations. These have been done in tap and river water samples (100–250 mL, 15–500 µg L −1 Irbesartan), obtaining quantitative sorption/desorption on the MIP-polyHIPE (RSD < 14%, n = 3). The NIP provided a recovery of just around 30%, evidence of partial uptake of the target from water.

Keywords: polyHIPE; molecularly imprinted polymers; environmental waters; pharmaceuticals; pollutants; solid-phase extraction; water purification (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2023
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