Tendon Disorders in Chronic Liver Disease: A Retrospective Cohort Study in Taiwan

Ching-Yueh Lin, Shih-Chung Huang, Shiow-Jyu Tzou, Chun-Hao Yin, Jin-Shuen Chen, Yao-Shen Chen and Shin-Tsu Chang ()
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Ching-Yueh Lin: Department of Physical Medicine and Rehabilitation, Kaohsiung Armed Forces General Hospital, Kaohsiung 802301, Taiwan
Shih-Chung Huang: Division of Cardiology, Department of Internal Medicine, Kaohsiung Armed Forces General Hospital, Kaohsiung 802301, Taiwan
Shiow-Jyu Tzou: Institute of Medical Science and Technology, National Sun Yat-sen University, Kaohsiung 804201, Taiwan
Chun-Hao Yin: Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung 813414, Taiwan
Jin-Shuen Chen: Department of Administration, Kaohsiung Veterans General Hospital, Kaohsiung 813414, Taiwan
Yao-Shen Chen: Department of Administration, Kaohsiung Veterans General Hospital, Kaohsiung 813414, Taiwan
Shin-Tsu Chang: Department of Physical Medicine and Rehabilitation, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei 114202, Taiwan

IJERPH, 2023, vol. 20, issue 6, 1-11

Abstract: To investigate the relationship between chronic liver disease and tendon disorder, a retrospective cohort study was conducted using the Kaohsiung Veterans General Hospital database. Patients >18 years with newly diagnosed liver disease and with at least a two-year follow-up in the hospital were included. An equal number of 20,479 cases were enrolled in both the liver-disease and non-liver-disease groups using a propensity score matching method. Disease was defined using ICD-9 or ICD-10 codes. The primary outcome was the development of tendon disorder. Demographic characteristics, comorbidities, use of tendon-toxic drugs, and status of HBV/HCV infection were included for analysis. The results showed 348 (1.7%) and 219 (1.1%) individuals developed tendon disorder in the chronic liver disease group and non-liver-disease group. Concomitant use of glucocorticoids and statins may have further raised the risk of tendon disorder in the liver disease group. The co-existence of HBV/HCV infection did not increase the risk of tendon disorder in the patients with liver disease. Considering these findings, physicians should be more aware of tendon issues in advance, and a prophylactic strategy should be adopted in patients with chronic liver disease.

Keywords: betel nut; chronic liver disease; glucocorticoids; statins; tendinopathy; tendon disorder (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2023
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