Evaluating Processing Speed and Reaction Time Outcome Measures in Children and Adolescents with Down Syndrome

Emily K. Schworer (), Mekibib Altaye, Deborah J. Fidler, Dean W. Beebe, Susan Wiley, Emily K. Hoffman and Anna J. Esbensen
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Emily K. Schworer: Division of Developmental and Behavioral Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA
Mekibib Altaye: Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
Deborah J. Fidler: Human Development and Family Studies, Colorado State University, Fort Collins, CO 80523, USA
Dean W. Beebe: Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
Susan Wiley: Division of Developmental and Behavioral Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA
Emily K. Hoffman: Division of Developmental and Behavioral Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA
Anna J. Esbensen: Division of Developmental and Behavioral Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA

IJERPH, 2023, vol. 20, issue 6, 1-15

Abstract: Reliable and valid cognitive outcome measures, including examiner-administered and computer-facilitated assessments of processing speed and reaction time, are necessary for future clinical trials that include individuals with Down syndrome (DS). The current study evaluated the score distributions and psychometric properties of four examiner-administered and three computerized processing speed and reaction time measures. Participants included 97 individuals with DS, aged 6 to 17 (M = 12.6, SD = 3.3). Two examiner-administered measures (Differential Ability Scales-II Rapid Naming and Cat/dog Stroop Congruent) met most predetermined psychometric criteria. Other assessments demonstrated good test-retest reliability and had negligible practice effects but lacked adequate feasibility. Recommendations for using processing speed and reaction time assessments in research and suggestions for modifications of measures are discussed.

Keywords: Down syndrome; processing speed; outcome measures; cognition; clinical trials (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2023
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