Pain and Motor Function in Myotonic Dystrophy Type 1: A Cross-Sectional Study

Sara Liguori, Antimo Moretti (), Giuseppe Toro, Marco Paoletta, Angela Palomba, Giuseppe Barra, Francesca Gimigliano and Giovanni Iolascon
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Sara Liguori: Department of Medical and Surgical Specialties and Dentistry, University of Campania “Luigi Vanvitelli”, Via De Crecchio n. 4, 80138 Naples, Italy
Antimo Moretti: Department of Medical and Surgical Specialties and Dentistry, University of Campania “Luigi Vanvitelli”, Via De Crecchio n. 4, 80138 Naples, Italy
Giuseppe Toro: Department of Medical and Surgical Specialties and Dentistry, University of Campania “Luigi Vanvitelli”, Via De Crecchio n. 4, 80138 Naples, Italy
Marco Paoletta: Department of Medical and Surgical Specialties and Dentistry, University of Campania “Luigi Vanvitelli”, Via De Crecchio n. 4, 80138 Naples, Italy
Angela Palomba: Department of Medical and Surgical Specialties and Dentistry, University of Campania “Luigi Vanvitelli”, Via De Crecchio n. 4, 80138 Naples, Italy
Giuseppe Barra: Post Intensive Functional Rehabilitation Unit, Istituto di Diagnosi e Cura Hermitage Capodimonte, 80131 Naples, Italy
Francesca Gimigliano: Department of Mental and Physical Health and Preventive Medicine, University of Campania “Luigi Vanvitelli”, Largo Madonna delle Grazie n. 1, 80138 Naples, Italy
Giovanni Iolascon: Department of Medical and Surgical Specialties and Dentistry, University of Campania “Luigi Vanvitelli”, Via De Crecchio n. 4, 80138 Naples, Italy

IJERPH, 2023, vol. 20, issue 7, 1-11

Abstract: Pain is an underestimated finding in myotonic dystrophy type 1 (DM1). We provide a characterization of pain in terms of functional implications through a multidimensional assessment in patients with DM1, focusing on gender differences. We assessed pain through the Brief Pain Inventory (BPI) and its indexes (the Severity Index (SI) and the Interference Index (II)), balance/gait (the Tinetti Performance-Oriented Mobility Assessment (POMA)), functional abilities (the Functional Independence Measure (FIM)), and fatigue (the Fatigue Severity Scale (FSS)). We divided our sample into a mild (<4) and a moderate–severe group (≥4) based on BPI indexes. A between-group analysis was performed. We recruited 23 males and 22 females with DM1. A statistically significant difference was found for the FSS and the BPI-SI ≥ 4, and for all outcomes in the BPI-II ≥ 4 ( p ≤ 0.003). In the female group, all outcomes except for the FIM were statistically significantly worse ( p ≤ 0.004). Dividing our sample into four groups based on gender and the BPI, a statistically significant difference was found for FSS between the two groups with BPI-II ≥ 4 (with worsen score in the female one) ( p < 0.002). Pain in DM1 patients is highly reported and gender related, with increased fatigue and poor balance/gait in the female group.

Keywords: pain; myotonic dystrophy type 1; gender; fatigue; balance; gait; disability evaluation (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2023
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