Distinct Predictors of Clinical Response after Repetitive Transcranial Magnetic Stimulation between Bipolar and Unipolar Disorders

Aurélie Lacroix (), Aude Paquet, Mireille Okassa, Théodore Vinais, Marilyne Lannaud, Brigitte Plansont, Alexandre Buisson, Sandrine Guignandon, Dominique Malauzat, Murielle Girard and Benjamin Calvet
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Aurélie Lacroix: Unité de Recherche et d’Innovation, Centre Hospitalier Esquirol, 87025 Limoges, France
Aude Paquet: Unité de Recherche et d’Innovation, Centre Hospitalier Esquirol, 87025 Limoges, France
Mireille Okassa: Unité de Recherche et d’Innovation, Centre Hospitalier Esquirol, 87025 Limoges, France
Théodore Vinais: Unité de Recherche et d’Innovation, Centre Hospitalier Esquirol, 87025 Limoges, France
Marilyne Lannaud: Unité de Recherche et d’Innovation, Centre Hospitalier Esquirol, 87025 Limoges, France
Brigitte Plansont: Unité de Recherche et d’Innovation, Centre Hospitalier Esquirol, 87025 Limoges, France
Alexandre Buisson: Unité de Recherche et d’Innovation, Centre Hospitalier Esquirol, 87025 Limoges, France
Sandrine Guignandon: Unité de Recherche et d’Innovation, Centre Hospitalier Esquirol, 87025 Limoges, France
Dominique Malauzat: Unité de Recherche et d’Innovation, Centre Hospitalier Esquirol, 87025 Limoges, France
Murielle Girard: Unité de Recherche et d’Innovation, Centre Hospitalier Esquirol, 87025 Limoges, France
Benjamin Calvet: Unité de Recherche et d’Innovation, Centre Hospitalier Esquirol, 87025 Limoges, France

IJERPH, 2023, vol. 20, issue 7, 1-10

Abstract: Background: Repetitive transcranial magnetic stimulation (rTMS) has been shown to be therapeutically effective for patients suffering from drug-resistant depression. The distinction between bipolar and unipolar disorders would be of great interests to better adapt their respective treatments. Methods: We aimed to identify the factors predicting clinical improvement at one month (M1) after the start of rTMS treatment for each diagnosis, which was preceded by a comparison of the patients’ clinical conditions. We used the data collected and the method employed in a previous publication on 291 patients. Results: Although the bipolar group had fewer responders, these patients seemed to better maintain their post-rTMS improvement on anxiety and perception of the severity of their illness than those in the unipolar group. For the bipolar group, young age coupled with low number of medications and high fatigue was shown to be the best combination for predicting improvement at M1. The duration of current depressive episode, which was previously demonstrated for whole group, combined with being attached was shown to favor clinical improvement among the patients in unipolar group. Conclusion: We were able to define a combination of specific factors related to each diagnosis for predicting the patients’ clinical response. This could be extremely useful to predict the efficacy of rTMS during routine clinical practice in neuromodulation services.

Keywords: rTMS; bipolar disorder; unipolar disorder; drug-resistant depression; care; clinical response; predictors (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2023
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