Liver Function in Patients with Long-Term Coronavirus Disease 2019 of up to 20 Months: A Cross-Sectional Study

Igor Costa de Lima, Daniel Carvalho de Menezes, Juliana Hiromi Emin Uesugi, Cléa Nazaré Carneiro Bichara, Pedro Fernando da Costa Vasconcelos, Juarez Antônio Simões Quaresma and Luiz Fábio Magno Falcão ()
Additional contact information
Igor Costa de Lima: Center for Biological Health Sciences, State University of Pará, Belém 66087670, Brazil
Daniel Carvalho de Menezes: Center for Biological Health Sciences, State University of Pará, Belém 66087670, Brazil
Juliana Hiromi Emin Uesugi: Center for Biological Health Sciences, State University of Pará, Belém 66087670, Brazil
Cléa Nazaré Carneiro Bichara: Center for Biological Health Sciences, State University of Pará, Belém 66087670, Brazil
Pedro Fernando da Costa Vasconcelos: Center for Biological Health Sciences, State University of Pará, Belém 66087670, Brazil
Juarez Antônio Simões Quaresma: Center for Biological Health Sciences, State University of Pará, Belém 66087670, Brazil
Luiz Fábio Magno Falcão: Center for Biological Health Sciences, State University of Pará, Belém 66087670, Brazil

IJERPH, 2023, vol. 20, issue 7, 1-11

Abstract: The long-term laboratory aspects of the effects of coronavirus disease 2019 (COVID-19) on liver function are still not well understood. Therefore, this study aimed to evaluate the hepatic clinical laboratory profile of patients with up to 20 months of long-term COVID-19. A total of 243 patients of both sexes aged 18 years or older admitted during the acute phase of COVID-19 were included in this study. Liver function analysis was performed. Changes were identified in the mean levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), gamma-glutamyl transferase (GGT), and ferritin. A ferritin level of >300 U/L was observed in the group that presented more changes in liver function markers (ALT, AST, and GGT). Age ? 60 years, male sex, AST level > 25 U/L, and GGT level ? 50 or 32 U/L were associated with an ALT level > 29 U/L. A correlation was found between ALT and AST, LDH, GGT, and ferritin. Our findings suggest that ALT and AST levels may be elevated in patients with long-term COVID-19, especially in those hospitalised during the acute phase. In addition, an ALT level > 29 U/L was associated with changes in the levels of other markers of liver injury, such as LDH, GGT, and ferritin.

Keywords: COVID-19; post-COVID; liver; aspartate aminotransferase; risk factors (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2023
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.mdpi.com/1660-4601/20/7/5281/pdf (application/pdf)
https://www.mdpi.com/1660-4601/20/7/5281/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:20:y:2023:i:7:p:5281-:d:1109049

Access Statistics for this article

IJERPH is currently edited by Ms. Jenna Liu

More articles in IJERPH from MDPI
Bibliographic data for series maintained by MDPI Indexing Manager ().