Perioperative Management of Antithrombotic Therapy in Patients Who Undergo Dental Procedures: A Systematic Review of the Literature and Network Meta-Analysis

Andrea Boccatonda, Alessio Frisone, Felice Lorusso, Calogero Bugea, Maristella Di Carmine, Cosima Schiavone, Giulio Cocco, Damiano D’Ardes, Antonio Scarano () and Maria Teresa Guagnano ()
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Andrea Boccatonda: Internal Medicine, Bentivoglio Hospital, AUSL Bologna, 40010 Bentivoglio, Italy
Alessio Frisone: Department of Innovative Technologies in Medicine & Dentistry, University of Chieti-Pescara, Via Dei Vestini 31, 66100 Chieti, Italy
Felice Lorusso: Department of Innovative Technologies in Medicine & Dentistry, University of Chieti-Pescara, Via Dei Vestini 31, 66100 Chieti, Italy
Calogero Bugea: Department of Innovative Technologies in Medicine & Dentistry, University of Chieti-Pescara, Via Dei Vestini 31, 66100 Chieti, Italy
Maristella Di Carmine: Department of Innovative Technologies in Medicine & Dentistry, University of Chieti-Pescara, Via Dei Vestini 31, 66100 Chieti, Italy
Cosima Schiavone: Department of Medicine and Science of Aging, “G. d’Annunzio” University, 66100 Chieti, Italy
Giulio Cocco: Department of Medicine and Science of Aging, “G. d’Annunzio” University, 66100 Chieti, Italy
Damiano D’Ardes: Department of Medicine and Science of Aging, “G. d’Annunzio” University, 66100 Chieti, Italy
Antonio Scarano: Department of Innovative Technologies in Medicine & Dentistry, University of Chieti-Pescara, Via Dei Vestini 31, 66100 Chieti, Italy
Maria Teresa Guagnano: Department of Medicine and Science of Aging, “G. d’Annunzio” University, 66100 Chieti, Italy

IJERPH, 2023, vol. 20, issue 7, 1-13

Abstract: Background: The surgical dental treatment of subjects admitted for anticoagulants therapy represents a consistent risk for peri-operative bleeding. The aim of the present study was to investigate the clinical findings of dental surgery operative management of the patients under anticoagulants drugs protocol. Methods: The literature screening was performed using Pubmed/Medline, EMBASE and Cochrane library, considering only randomized clinical trials (RCTs) papers. No limitations about the publication’s period, follow-up time or clinical parameters were considered. Results: A total of eight RCTs were included for the qualitative synthesis. No thromboembolic complications were reported in any studies. Several bleeding episodes associated with anticoagulant drugs in dental surgery were mild and generally happened on the first day after the treatment. Conclusions: The use of local haemostatic measures is generally effective for bleeding control with no further pharmacological drug management or suspension.

Keywords: tooth extraction; oral surgery; haemostasis; oral haemorrhage; anticoagulants; antiplatelet therapy; antithrombotic therapy; atrial fibrillation and oral surgery (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2023
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