Potential Relationship between Poor Oral Hygiene and MRONJ: An Observational Retrospective Study

Silvia D’Agostino (), Giulia Valentini, Marco Dolci and Elisabetta Ferrara
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Silvia D’Agostino: Complex Unit of Odontostomatology, Interdisciplinary Department of Medicine, University Aldo Moro of Bari, 70121 Bari, Italy
Giulia Valentini: Department of Medical, Oral and Biotechnological Sciences, University Gabriele d’Annunzio, 66100 Chieti, Italy
Marco Dolci: Department of Medical, Oral and Biotechnological Sciences, University Gabriele d’Annunzio, 66100 Chieti, Italy
Elisabetta Ferrara: Department of Medical, Oral and Biotechnological Sciences, University Gabriele d’Annunzio, 66100 Chieti, Italy

IJERPH, 2023, vol. 20, issue 7, 1-9

Abstract: Medication-related osteonecrosis of the jaw (MRONJ) is a drug-related side effect linked but not limited to antiresorptive and antiangiogenic molecules. It recognizes several triggers in dental procedures, such as surgery, endodontic treatments, and root planing, but also prosthesis decubitus or with a spontaneous onset. Although there are many reports about the onset of this pathology, oral hygiene status is mainly described as a consequence of MRONJ. Not so much is known about the oral hygiene situation as a concurrent factor in the pathogenesis of severe stages and about non-surgical periodontal therapy in patients affected by MRONJ. Actually, clear instructions for non-surgical periodontal therapy are poor in the literature. The primary outcome of the present study is to evaluate the oral hygiene status in MRONJ patients. In addition, a secondary outcome is to review the factor of poor oral hygiene as a cause or worsening aspect for MRONJ. A total of 45 subjects (19 males and 26 females) with a mean age of 59 ± 12 were enrolled. The Pearson correlation coefficient showed no significant results for the variable of the Simplified Oral Hygiene Index (OHI-S) and the American Association of Oral and Maxillofacial Surgeons (AAOMS) stage, although the majority of patients showed poor oral hygiene with an OHI-S average of 3.39 ± 1.83. As stated by the last AAOMS position paper, poor plaque control is related to a worsened MRONJ stage. The relation between the lack of oral hygiene and MRONJ onset is still unclear.

Keywords: MRONJ; osteonecrosis; oral hygiene; non-surgical periodontal therapy (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2023
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