The Economic Impact of Post-Traumatic Stress Disorder Among Patients with Systemic Autoimmune Diseases During the COVID-19 Pandemic

Valentina Lorenzoni (), Gianni Andreozzi, Ilaria Palla, Chiara Tani, Claudia Carmassi, Giovanni Fulvio, Francesca Trentin, Sara Fantasia, Lorenzo Conti, Liliana Dell’Osso, Marta Mosca and Giuseppe Turchetti
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Valentina Lorenzoni: Intitute of Management, Scuola Superiore Sant’Anna, 56127 Pisa, Italy
Gianni Andreozzi: Intitute of Management, Scuola Superiore Sant’Anna, 56127 Pisa, Italy
Ilaria Palla: Intitute of Management, Scuola Superiore Sant’Anna, 56127 Pisa, Italy
Chiara Tani: Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy
Claudia Carmassi: Psychiatry Unit, Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy
Giovanni Fulvio: Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy
Francesca Trentin: Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy
Sara Fantasia: Psychiatry Unit, Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy
Lorenzo Conti: Psychiatry Unit, Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy
Liliana Dell’Osso: Psychiatry Unit, Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy
Marta Mosca: Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy
Giuseppe Turchetti: Intitute of Management, Scuola Superiore Sant’Anna, 56127 Pisa, Italy

IJERPH, 2024, vol. 21, issue 11, 1-16

Abstract: Background: The present work aimed to estimate the economic impact of PTSD following COVID-19 in a population of patients affected by systemic autoimmune disease (SAD) using a cost-of-illness approach and accounting for the perspective of society. Methods: Considering data collected from SAD patients enrolled in a specialized outpatient clinic in the Tuscany region, Italy, generalized linear models and LASSO logistic regression were used to evaluate the impact of PTSD on costs and its relevance as a possible predictor of being a high-cost patient, respectively. Results: Considering 301 SAD patients, 161 (51.2%) of whom were diagnosed with PTSD, the overall costs were EUR 3670 [890; 40,529] per patient/year among patients with PTSD and EUR 2736.7 [283; 21,078] per patient/year among those without PTSD ( p -value < 0.001), with differences mainly attributable to significantly greater direct non-healthcare and indirect costs. PTSD was estimated to increase overall costs (β = 0.296 (0.140), p -value = 0.035), direct non-healthcare (β = 1.193 (0.392), p -value = 0.002), and indirect costs (β = 3.741 (1.136), p -value = 0.001). PTSD diagnosis was also significantly associated with the likelihood of being a high-cost patient. Conclusions: Findings from the present study offer a novel perspective on the economic impact of COVID-19 and provide valuable data for policymakers to better understand the demand for healthcare services and associated costs.

Keywords: COVID-19; post-traumatic stress disorder; systemic autoimmune disease; economic; healthcare costs; indirect costs; LASSO regression (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2024
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