Protective Effect of Silver Nanoparticles Against Cytosine Arabinoside Genotoxicity: An In Vivo Micronucleus Assay

Idalia Yazmin Castañeda-Yslas, Olivia Torres-Bugarín, María Evarista Arellano-García (), Balam Ruiz-Ruiz, Juan Carlos García-Ramos, Yanis Toledano-Magaña, Alexey Pestryakov and Nina Bogdanchikova ()
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Idalia Yazmin Castañeda-Yslas: Centro de Nanociencias y Nanotecnología, Universidad Nacional Autónoma de México, Ensenada 22860, Baja California, Mexico
Olivia Torres-Bugarín: Medicina Interna II, Decanato Facultad de Medicina, Universidad Autónoma de Guadalajara, Zapopan 45129, Jalisco, Mexico
María Evarista Arellano-García: Facultad de Ciencias, Universidad Autónoma de Baja California, Ensenada 22860, Baja California, Mexico
Balam Ruiz-Ruiz: Escuela de Ciencias de la Salud Unidad Valle Dorado, Universidad Autónoma de Baja California, Ensenada 22890, Baja California, Mexico
Juan Carlos García-Ramos: Instituto Tecnológico de Ensenada, Tecnológico Nacional de México, Ensenada 22780, Baja California, Mexico
Yanis Toledano-Magaña: Instituto Tecnológico de Ensenada, Tecnológico Nacional de México, Ensenada 22780, Baja California, Mexico
Alexey Pestryakov: Research School of Chemistry and Applied Biomedical Sciences, Tomsk Polytechnic University, Tomsk 634050, Russia
Nina Bogdanchikova: Centro de Nanociencias y Nanotecnología, Universidad Nacional Autónoma de México, Ensenada 22860, Baja California, Mexico

IJERPH, 2024, vol. 21, issue 12, 1-13

Abstract: Cancer treatments have harmful side effects, including genotoxic ones. Our previous research discovered that a specific silver nanoparticle (AgNPs) formulation could reduce the genotoxic effects of an alkylating agent, cyclophosphamide. This study aims to evaluate if this protective effect is observed against an antimetabolite anticancer agent, cytosine arabinoside (Ara-C). An erythrocyte micronucleus assay was conducted on BALB/c mice. A most significant effect was observed after the application scheme, including three doses of Ara-C and three subsequent doses of AgNPs, resulting in a 3.7 and 2.0-fold decrease in the frequency of micronucleated reticulocytes and accumulated erythrocytes, respectively. Current and previous studies reveal that AgNPs could be used as a genoprotector against the genotoxic damage produced by the currently used antineoplastic antimetabolites and alkylating agents. It was revealed that AgNPs could be considered a new class of promising synthetic antineoplastic genoprotectants along with the known class of derivatives from natural sources.

Keywords: genoprotective effect; silver nanoparticles; cytosine arabinoside; in vivo assay; micronucleus assay> (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2024
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