Impaired Well-Being and Insomnia as Residuals of Resolved Medical Conditions: Survey in the Italian Population

Danilo Menicucci, Luca Bastiani, Eleonora Malloggi, Francesca Denoth, Angelo Gemignani and Sabrina Molinaro ()
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Danilo Menicucci: Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine, University of Pisa, 56126 Pisa, Italy
Luca Bastiani: Institute of Clinical Physiology, National Research Council, 56124 Pisa, Italy
Eleonora Malloggi: Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine, University of Pisa, 56126 Pisa, Italy
Francesca Denoth: Institute of Clinical Physiology, National Research Council, 56124 Pisa, Italy
Angelo Gemignani: Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine, University of Pisa, 56126 Pisa, Italy
Sabrina Molinaro: Institute of Clinical Physiology, National Research Council, 56124 Pisa, Italy

IJERPH, 2024, vol. 21, issue 2, 1-19

Abstract: Background: Well-being encompasses physical, mental, social, and cultural aspects. Sleep quality and pathologies are among the objective conditions jeopardising it. Chronic insomnia, inflammatory-based diseases, and mood disorders often occur in a single cluster, and inflammation can negatively impact sleep, potentially harming well-being. Some evidence from specific clinical populations suggests that also some resolved past diseases could still have an impact on present sleep quality and well-being. The aim of the present study is to investigate, in the general population, whether and to what degree well-being and insomnia are associated with resolved pathologies. Methods: A cross-sectional survey (IPSAD ® ) was carried out using anonymous postal questionnaires that investigated past and present general health, well-being, and insomnia. A total of 10,467 subjects answered the questionnaire. Results: Several classes of both current and resolved pathologies resulted in increased odds ratios for current insomnia (odds ratios = 1.90; 1.43, respectively) and impaired well-being (odds ratios = 1.75; 1.33, respectively), proportional to the number of the displayed pathologies. Notably, both current and resolved past psychiatric disorders were strongly associated with both current impaired well-being (odds ratios = 5.38; 1.70, respectively) and insomnia (odds ratios = 4.99; 2.15, respectively). Conclusions: To explain these associations, we suggest that systemic inflammation conveyed by several medical conditions disrupts homeostatic processes, with final effects on sleep quality and behaviour.

Keywords: sleep; chronic inflammation; psychiatric disorders; anxiety; depression; clinical disorders (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2024
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