HIPTox—Hazard Identification Platform to Assess the Health Impacts from Indoor and Outdoor Air Pollutant Exposures, through Mechanistic Toxicology: A Single-Centre Double-Blind Human Exposure Trial Protocol

Thomas Faherty (), Huda Badri, Dawei Hu, Aristeidis Voliotis, Francis D. Pope, Ian Mudway, Jacky Smith and Gordon McFiggans
Additional contact information
Thomas Faherty: School of Geography, Earth and Environmental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
Huda Badri: Division of Infection, Immunity and Respiratory Medicine, University of Manchester, 2nd Floor Education and Research Centre, Wythenshawe Hospital, Southmoor Rd., Manchester M23 9LT, UK
Dawei Hu: Centre for Atmospheric Sciences, Department of Earth and Environmental Science, School of Natural Sciences, University of Manchester, Manchester M13 9PL, UK
Aristeidis Voliotis: Centre for Atmospheric Sciences, Department of Earth and Environmental Science, School of Natural Sciences, University of Manchester, Manchester M13 9PL, UK
Francis D. Pope: School of Geography, Earth and Environmental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
Ian Mudway: MRC Centre for Environment and Health, Imperial College London, London W12 0BZ, UK
Jacky Smith: Division of Infection, Immunity and Respiratory Medicine, University of Manchester, 2nd Floor Education and Research Centre, Wythenshawe Hospital, Southmoor Rd., Manchester M23 9LT, UK
Gordon McFiggans: Centre for Atmospheric Sciences, Department of Earth and Environmental Science, School of Natural Sciences, University of Manchester, Manchester M13 9PL, UK

IJERPH, 2024, vol. 21, issue 3, 1-18

Abstract: Over the past decade, our understanding of the impact of air pollution on short- and long-term population health has advanced considerably, focusing on adverse effects on cardiovascular and respiratory systems. There is, however, increasing evidence that air pollution exposures affect cognitive function, particularly in susceptible groups. Our study seeks to assess and hazard rank the cognitive effects of prevalent indoor and outdoor pollutants through a single-centre investigation on the cognitive functioning of healthy human volunteers aged 50 and above with a familial predisposition to dementia. Participants will all undertake five sequential controlled exposures. The sources of the air pollution exposures are wood smoke, diesel exhaust, cleaning products, and cooking emissions, with clean air serving as the control. Pre- and post-exposure spirometry, nasal lavage, blood sampling, and cognitive assessments will be performed. Repeated testing pre and post exposure to controlled levels of pollutants will allow for the identification of acute changes in functioning as well as the detection of peripheral markers of neuroinflammation and neuronal toxicity. This comprehensive approach enables the identification of the most hazardous components in indoor and outdoor air pollutants and further understanding of the pathways contributing to neurodegenerative diseases. The results of this project have the potential to facilitate greater refinement in policy, emphasizing health-relevant pollutants and providing details to aid mitigation against pollutant-associated health risks.

Keywords: air pollution; cognitive function; dementia; indoor air; human exposure; study protocol (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2024
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.mdpi.com/1660-4601/21/3/284/pdf (application/pdf)
https://www.mdpi.com/1660-4601/21/3/284/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:21:y:2024:i:3:p:284-:d:1348652

Access Statistics for this article

IJERPH is currently edited by Ms. Jenna Liu

More articles in IJERPH from MDPI
Bibliographic data for series maintained by MDPI Indexing Manager ().