Clinical and Neuroimaging Predictors of Alzheimer’s Dementia Conversion in Patients with Mild Cognitive Impairment Using Amyloid Positron Emission Tomography by Quantitative Analysis over 2 Years

Seonjeong Kim, Daye Yoon, Junho Seong, Young Jin Jeong, Do-Young Kang and Kyung Won Park ()
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Seonjeong Kim: Department of Neurology, Cognitive Disorders and Dementia Center, Dong-A University College of Medicine, Busan 49201, Republic of Korea
Daye Yoon: Department of Neurology, Cognitive Disorders and Dementia Center, Dong-A University College of Medicine, Busan 49201, Republic of Korea
Junho Seong: Department of Neurology, Cognitive Disorders and Dementia Center, Dong-A University College of Medicine, Busan 49201, Republic of Korea
Young Jin Jeong: Department of Nuclear Medicine, Dong-A University College of Medicine, Busan 49201, Republic of Korea
Do-Young Kang: Department of Nuclear Medicine, Dong-A University College of Medicine, Busan 49201, Republic of Korea
Kyung Won Park: Department of Neurology, Cognitive Disorders and Dementia Center, Dong-A University College of Medicine, Busan 49201, Republic of Korea

IJERPH, 2024, vol. 21, issue 5, 1-13

Abstract: Patients with mild cognitive impairment (MCI) have a relatively high risk of developing Alzheimer’s dementia (AD), so early identification of the risk for AD conversion can lessen the socioeconomic burden. In this study, 18 F-Florapronol, newly developed in Korea, was used for qualitative and quantitative analyses to assess amyloid positivity. We also investigated the clinical predictors of the progression from MCI to dementia over 2 years. From December 2019 to December 2022, 50 patients with MCI were recruited at a single center, and 34 patients were included finally. Based on visual analysis, 13 (38.2%) of 34 participants were amyloid-positive, and 12 (35.3%) were positive by quantitative analysis. Moreover, 6 of 34 participants (17.6%) converted to dementia after a 2-year follow-up ( p = 0.173). Among the 15 participants who were positive for amyloid in the posterior cingulate region, 5 (33.3%) patients developed dementia ( p = 0.066). The Clinical Dementia Rating-Sum of Boxes (CDR-SOB) at baseline was significantly associated with AD conversion in multivariate Cox regression analyses ( p = 0.043). In conclusion, these results suggest that amyloid positivity in the posterior cingulate region and higher CDR-SOB scores at baseline can be useful predictors of AD conversion in patients with MCI.

Keywords: mild cognitive impairment; Alzheimer’s dementia; amyloid positron emission tomography; 18 F-Florapronol; posterior cingulate; clinical predictor (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2024
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