An Assessment of the Ocular Toxicity of Two Major Sources of Environmental Exposure

Steven H. Rauchman, Lora J. Kasselman, Ankita Srivastava, Joshua De Leon and Allison B. Reiss ()
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Steven H. Rauchman: The Fresno Institute of Neuroscience, Fresno, CA 93730, USA
Lora J. Kasselman: Research Institute, Hackensack Meridian Health, Edison, NJ 08502, USA
Ankita Srivastava: Department of Medicine and Biomedical Research Institute, NYU Grossman Long Island School of Medicine, Mineola, NY 11501, USA
Joshua De Leon: Department of Medicine and Biomedical Research Institute, NYU Grossman Long Island School of Medicine, Mineola, NY 11501, USA
Allison B. Reiss: Department of Medicine and Biomedical Research Institute, NYU Grossman Long Island School of Medicine, Mineola, NY 11501, USA

IJERPH, 2024, vol. 21, issue 6, 1-12

Abstract: The effect of airborne exposure on the eye surface is an area in need of exploration, particularly in light of the increasing number of incidents occurring in both civilian and military settings. In this study, in silico methods based on a platform comprising a portfolio of software applications and a technology ecosystem are used to test potential surface ocular toxicity in data presented from Iraqi burn pits and the East Palestine, Ohio, train derailment. The purpose of this analysis is to gain a better understanding of the long-term impact of such an exposure to the ocular surface and the manifestation of surface irritation, including dry eye disease. In silico methods were used to determine ocular irritation to chemical compounds. A list of such chemicals was introduced from a number of publicly available sources for burn pits and train derailment. The results demonstrated high ocular irritation scores for some chemicals present in these exposure events. Such an analysis is designed to provide guidance related to the needed ophthalmologic care and follow-up in individuals who have been in proximity to burn pits or the train derailment and those who will experience future toxic exposure.

Keywords: toxic chemical; environmental exposure; dry eye disease; Iraq burn pit emissions; ocular surface (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2024
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