A Systematic Review on the In Vivo Studies on Radiofrequency (100 kHz–300 GHz) Electromagnetic Field Exposure and Co-Carcinogenesis

Rosanna Pinto (), Lucia Ardoino, Paola Giardullo, Paola Villani and Carmela Marino
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Rosanna Pinto: Division of Biotechnologies at ENEA, Italian National Agency for New Technologies, Energy, Environment and Sustainable Economic Development, Via Anguillarese, 301, 00123 Rome, Italy
Lucia Ardoino: Division of Biotechnologies at ENEA, Italian National Agency for New Technologies, Energy, Environment and Sustainable Economic Development, Via Anguillarese, 301, 00123 Rome, Italy
Paola Giardullo: Division of Biotechnologies at ENEA, Italian National Agency for New Technologies, Energy, Environment and Sustainable Economic Development, Via Anguillarese, 301, 00123 Rome, Italy
Paola Villani: Division of Biotechnologies at ENEA, Italian National Agency for New Technologies, Energy, Environment and Sustainable Economic Development, Via Anguillarese, 301, 00123 Rome, Italy
Carmela Marino: Division of Biotechnologies at ENEA, Italian National Agency for New Technologies, Energy, Environment and Sustainable Economic Development, Via Anguillarese, 301, 00123 Rome, Italy

IJERPH, 2024, vol. 21, issue 8, 1-29

Abstract: In this systematic review, the potential role of in vivo RF–EMF exposure combined with the administration of well-known carcinogens in tumor promotion/progression is assessed. A total of 25 papers were included in the review. Each paper was assessed for Risk of Bias and for the attribution of the quality category. A meta-analysis was conducted on 18 studies, analyzing data for nine different organs/tumors to assess the potential increased risk for the onset of tumors as well as the effects on survival. A descriptive review was performed for the remaining seven eligible papers. In most cases, the results of the meta-analysis did not reveal a statistically significant difference in tumor onset between the sham and co-exposed samples. There was a numerically small increase in the risk of malignant tumors observed in the kidney and liver, as well as benign lung tumors. The level of evidence for health effects indicated “inadequate” evidence for an association between in vivo co-exposure to RF–EMF and known carcinogens and the onset of malignant or benign tumors in most of the analyzed tissues. Nevertheless, the limited number of eligible papers/studies for most of the analyzed tissues suggests that these results cannot be considered definitively conclusive.

Keywords: electromagnetic fields; in vivo studies; co-carcinogenesis; tumor incidence; survival (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2024
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