Maximal Oxygen Consumption Is Negatively Associated with Fat Mass in Facioscapulohumeral Dystrophy

Oscar Crisafulli, Luca Grattarola, Giorgio Bottoni, Jessica Lacetera, Emanuela Lavaselli, Matteo Beretta-Piccoli, Rossella Tupler, Emiliano Soldini and Giuseppe D’Antona ()
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Oscar Crisafulli: CRIAMS-Sport Medicine Centre Voghera, University of Pavia, 27058 Voghera, Italy
Luca Grattarola: CRIAMS-Sport Medicine Centre Voghera, University of Pavia, 27058 Voghera, Italy
Giorgio Bottoni: CRIAMS-Sport Medicine Centre Voghera, University of Pavia, 27058 Voghera, Italy
Jessica Lacetera: CRIAMS-Sport Medicine Centre Voghera, University of Pavia, 27058 Voghera, Italy
Emanuela Lavaselli: CRIAMS-Sport Medicine Centre Voghera, University of Pavia, 27058 Voghera, Italy
Matteo Beretta-Piccoli: CRIAMS-Sport Medicine Centre Voghera, University of Pavia, 27058 Voghera, Italy
Rossella Tupler: Department of Life Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy
Emiliano Soldini: Competence Centre for Healthcare Practices and Policies, Department of Business Economics, Health and Social Care, University of Applied Sciences and Arts of Southern Switzerland, 6928 Manno, Switzerland
Giuseppe D’Antona: CRIAMS-Sport Medicine Centre Voghera, University of Pavia, 27058 Voghera, Italy

IJERPH, 2024, vol. 21, issue 8, 1-11

Abstract: Facioscapulohumeral dystrophy (FSHD) leads to progressive changes in body composition such as loss of muscle mass and increase in adiposity. In healthy subjects, anthropometric parameters are associated with the maximum volume of oxygen consumed per minute (VO 2 max), which is a health and function indicator in several populations of subjects, both healthy and pathological. Since VO 2 max can be difficult to test in patients with FSHD due to exercise intolerance, the identification of associated anthropometric parameters could provide new easily obtainable elements for the patients’ clinical stratification. The aim of this study was to evaluate whether anthropometric and body composition parameters are associated with VO 2 max in patients with FSHD. A total of 22 subjects with a molecular genetics-based diagnosis of FSHD (6 females, 16 males, mean age of 35.18 years) were recruited for the study. VO 2 max was measured by cardiopulmonary exercise tests (CPETs) on a cycle ergometer, utilizing a step incremental technique (15 Watts (W) every 30 s). Weight (Kg) and height (m) were obtained and utilized to calculate body mass index (BMI). Body composition parameters (fat mass (FM), fat free mass (FFM), and body cell mass (BCM)) were obtained by bioelectrical impedance analysis (BIA). Significant negative associations were found between VO 2 max and FM (Spearman correlation coefficient (SCC) −0.712), BMI (SCC −0.673), age (SCC −0.480), and weight (SCC −0.634), unlike FFM and BCM. Our results indicate that FM, BMI, age, and body weight are negatively associated with VO 2 max in patients with FSHD. This evidence may help practitioners to better stratify patients with FSHD.

Keywords: FSHD; body composition; muscular dystrophy; aerobic fitness; clinical stratification (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2024
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