Adherence to Antihypertensive Therapy: A Cross-Sectional Study Among Patients in the Republic of Kazakhstan

Akbayan Markabayeva (), Aiman Kerimkulova, Riza Nurpeissova, Gyulnar Zhussupova, Ayagyoz Umbetzhanova, Dinara Zhunussova, Alisher Idrisov, Ardak Zhumagaliyeva, Aliya Seidullayeva, Aigul Utegenova and Lyudmila Pivina
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Akbayan Markabayeva: Department of Family Medicine No. 2, NJSC “Astana Medical University”, Beibitshilik Str. 49a, Astana 010000, Kazakhstan
Aiman Kerimkulova: Department of Family Medicine No. 2, NJSC “Astana Medical University”, Beibitshilik Str. 49a, Astana 010000, Kazakhstan
Riza Nurpeissova: Department of Family Medicine No. 2, NJSC “Astana Medical University”, Beibitshilik Str. 49a, Astana 010000, Kazakhstan
Gyulnar Zhussupova: Heart Rhythm Research Institute, NJSC “Astana Medical University”, Beibitshilik Str. 49a, Astana 010000, Kazakhstan
Ayagyoz Umbetzhanova: Department of General Practice with the Course of Evidence-Based Medicine, NJSC “Astana Medical University”, Beibitshilik Str. 49a, Astana 010000, Kazakhstan
Dinara Zhunussova: Department of General Practice with the Course of Evidence-Based Medicine, NJSC “Astana Medical University”, Beibitshilik Str. 49a, Astana 010000, Kazakhstan
Alisher Idrisov: Department of Family Medicine No. 2, NJSC “Astana Medical University”, Beibitshilik Str. 49a, Astana 010000, Kazakhstan
Ardak Zhumagaliyeva: Department of Family Medicine No. 2, NJSC “Astana Medical University”, Beibitshilik Str. 49a, Astana 010000, Kazakhstan
Aliya Seidullayeva: Department of Pediatric Infectious Diseases, NJSC “Astana Medical University”, Beibitshilik Str. 49a, Astana 010000, Kazakhstan
Aigul Utegenova: Department of Microbiology and Virology, NJSC “Astana Medical University”, Beibitshilik Str. 49a, Astana 010000, Kazakhstan
Lyudmila Pivina: Department of Emergency Medicine, NJSC “Semey Medical University”, Abay Str. 103, Semey 071400, Kazakhstan

IJERPH, 2025, vol. 22, issue 10, 1-14

Abstract: Background: Poor adherence to antihypertensive therapy is a major barrier to effective blood pressure control, particularly in countries with a high burden of non-communicable diseases. In Kazakhstan, improving adherence is a key objective of the “Densaulyk” State Health Program (2020–2025). Objective: To assess medication adherence among patients with arterial hypertension in Kazakhstan and identify associated socio-demographic and clinical factors. Methods: A cross-sectional survey was conducted among outpatient hypertensive patients at a major urban medical center. Adherence was measured using the 8-item Morisky Medication Adherence Scale (MMAS-8). Socio-demographic characteristics, disease duration, and the number of prescribed medications were analyzed in relation to adherence levels. Results: Adherence was significantly associated with age, ethnicity, education, marital and financial status, disease duration, and treatment complexity. A notable share of participants demonstrated low to moderate adherence. The use of self-reported data may have introduced bias. Conclusions: Medication adherence in Kazakhstan is influenced by multiple interrelated factors. Targeted and culturally appropriate interventions—such as simplified regimens, digital tools, and broader access to subsidized drugs—are essential to improve long-term outcomes in hypertension management.

Keywords: arterial hypertension; medication adherence; MMAS-8; Kazakhstan; non-communicable diseases; public health policy (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2025
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