Nutritional Association of Quality of Life Among Colorectal Cancer Survivors in Malaysia: A 6-Month Follow-Up Study

Ainaa Almardhiyah Abd Rashid, Hamid Jan Jan Mohamed (), Amal K. Mitra, Lydiatul Shima Ashari, Mohd Razif Shahril, Lee Yeong Yeh and Raja Affendi Raja Ali
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Ainaa Almardhiyah Abd Rashid: Nutrition Program, Faculty of Food Science and Nutrition, Universiti Malaysia Sabah, Kota Kinabalu 88400, Sabah, Malaysia
Hamid Jan Jan Mohamed: Nutrition Program, School of Health Sciences, Universiti Sains Malaysia, Kubang Kerian 16150, Kelantan, Malaysia
Amal K. Mitra: Department of Public Health, Julia Jones Matthews School of Population and Public Health, Texas Tech University Health Sciences Center, Abilene, TX 79601, USA
Lydiatul Shima Ashari: Nutrition Program, School of Health Sciences, Universiti Sains Malaysia, Kubang Kerian 16150, Kelantan, Malaysia
Mohd Razif Shahril: Centre for Healthy Aging and Wellness (HCARE), Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur 50300, Malaysia
Lee Yeong Yeh: Department of Medicine, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian 16150, Kelantan, Malaysia
Raja Affendi Raja Ali: Sir Jeffrey Cheah Sunway Medical School, Faculty of Medical and Life Sciences, Sunway University, Petaling Jaya 47500, Selangor, Malaysia

IJERPH, 2025, vol. 22, issue 11, 1-13

Abstract: Background: Quality of life (QoL) is a crucial outcome measure in cancer care. This study aimed to identify the association of health-related quality of life (HRQoL) among colorectal cancer (CRC) patients in Malaysia. Methods: The study was conducted from January 2021 to July 2022, recruiting CRC patients from two teaching hospitals in Malaysia. The validated Malay versions of EORTC QLQ-C30 and QLQ-CR29 questionnaires assessed physical, psychological, and social functioning. Patients were evaluated 6 months after diagnosis to determine QoL associations. Anthropometric measurements were recorded at baseline (diagnosis, 0 months) and at follow-up (6 months). Results: Among 87 CRC patients (55.2% male, mean age 59.8 ± 11.8 years), 37.9% had stage III disease and 13.8% had stage IV. Most patients (93%) underwent surgery and 78% received chemotherapy. The mean global health status score was 66.57 ± 20.75. Multiple linear regression analysis revealed that older age ( p = 0.03), advanced cancer stage ( p = 0.017), lower body weight ( p = 0.017), and reduced hip circumference ( p = 0.040) are significantly associated with poorer global health status quality of life (GHS QoL). Nutritional parameters specifically predicted functional domains: lower body weight and BMI predicted role and cognitive function, while lower hip circumference predicted emotional function. Conclusions: Advanced age, disease stage, and nutritional status are significant associations of QoL in Malaysian CRC patients. These findings highlight the importance of nutritional assessment and intervention in CRC survivorship care to optimize patient outcomes.

Keywords: colorectal cancer; health-related quality of life; nutritional parameters; follow-up study; Malaysia (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2025
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