Influence of CYP2C8 Polymorphism on the Exposure to Chloroquine in Patients with Malaria by Plasmodium vivax —A Preliminary Study

Luann Wendel Pereira de Sena (), Hellen Thais Fuzii, Fabiola Elizabeth Villanova, Amanda Gabryelle Nunes Cardoso Mello, Maria Pantoja Moreira de Sena, Michelle Valéria Dias Ferreira and José Luiz Fernandes Vieira ()
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Luann Wendel Pereira de Sena: College of Collective Health, Federal University of the South and Southeast of Para, Cidade Universitaria, Avenida dos Ipês s/n, Maraba 68500000, Para, Brazil
Hellen Thais Fuzii: Tropical Medicine Center, Para Federal University, Generalissimo Deodoro Street 92, Belem 66074740, Para, Brazil
Fabiola Elizabeth Villanova: Tropical Medicine Center, Para Federal University, Generalissimo Deodoro Street 92, Belem 66074740, Para, Brazil
Amanda Gabryelle Nunes Cardoso Mello: Pharmacy Faculty, Para Federal University, Campus Universitario do Guama, Augusto Correa Street 01, Belem 66074740, Para, Brazil
Maria Pantoja Moreira de Sena: Postgraduate Program in Tropical Diseases, Para Federal University, Generalissimo Deodoro Street 92, Belem 66074740, Para, Brazil
Michelle Valéria Dias Ferreira: Pharmacy Faculty, Para Federal University, Campus Universitario do Guama, Augusto Correa Street 01, Belem 66074740, Para, Brazil
José Luiz Fernandes Vieira: Pharmacy Faculty, Para Federal University, Campus Universitario do Guama, Augusto Correa Street 01, Belem 66074740, Para, Brazil

IJERPH, 2025, vol. 22, issue 3, 1-5

Abstract: Aim: To assess the impact of the CYP2C82 polymorphism on chloroquine and desethylchloroquine concentrations in patients with malaria caused by P. vivax . Methods: A prospective study was conducted on patients with malaria in an endemic area of the Amazon basin. Liquid chromatography was employed to measure the levels of chloroquine and desethylchloroquine, while molecular methods estimated the frequency of the CYP2C82 variant. Results: This study revealed that plasma levels of chloroquine were higher in patients with the CYP2C82 polymorphism compared to those without this variant. The difference in plasma levels ranged from 5% to 26.5%. Conversely, patients with the CYP2C82 polymorphism exhibited lower levels of desethylchloroquine. Conclusion: The findings of this study confirm the impairment of chloroquine metabolism by the CYP2C82 variant. However, it is noteworthy that in the dose regimen used for malaria treatment, these changes did not lead to toxic concentrations of the drug.

Keywords: malaria; polymorphism; chloroquine; Plasmodium vivax (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2025
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