Barriers to Immunosuppressant Medication Adherence in Thoracic Transplant Recipients: Initial Findings

Sparkle Springfield-Trice (), Grishma Reddy, Cara Joyce, Benito M. Garcia, Palak Shah, Sean Agbor-Enoh and Hannah Valantine
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Sparkle Springfield-Trice: Department of Public Health Sciences, Parkinson School of Health Sciences and Public Health, Loyola University Chicago, Maywood, IL 60153, USA
Grishma Reddy: Department of Public Health Sciences, Parkinson School of Health Sciences and Public Health, Loyola University Chicago, Maywood, IL 60153, USA
Cara Joyce: Department of Medicine, Stritch School of Medicine, Loyola University Chicago, 2160 S 1st Ave, Maywood, IL 60153, USA
Benito M. Garcia: Department of Surgery, School of Medicine, University of Minnesota, Minneapolis, MN 55455, USA
Palak Shah: Inova Schar Heart and Vascular, Falls Church, VA 22042, USA
Sean Agbor-Enoh: School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
Hannah Valantine: School of Medicine, Stanford University, Stanford, CA 94305, USA

IJERPH, 2025, vol. 22, issue 7, 1-30

Abstract: Although transplantation remains the gold-standard treatment for patients with end-organ failure, lifelong adherence to immunosuppressant medication is required to prevent rejection, graft failure, and mortality. Given the increase in thoracic organ transplantation, it is crucial to better understand the associated barriers to treatment. Examining sociodemographic, transplant, healthcare access, post-transplant treatment, and patient-related psychosocial factors may help to elucidate treatment barriers that have not been previously considered in the existing literature. This single-site cross-sectional study surveyed 65 thoracic (heart and lung) transplant recipients (mean age: 62 years; 76.2% male; 72.3% White, and 21.5% Black) via phone interviews. Immunosuppressant nonadherence was found in 49.2% of participants (46.9% heart, 51.5% lung). In a four-week period, 20% of participants missed at least one dose, 40% did not take their medications on time, and 1% stopped completely. Significant correlates of nonadherence included poorer diet quality, fewer comorbidities, and maladaptive coping responses to perceived discrimination. This preliminary study highlights the importance of considering the social determinants of health—particularly post-transplant treatment and psychosocial patient-related factors—to inform post-transplant care. Addressing such variables may improve medication adherence and, subsequently, overall health outcomes. Further research with larger samples is needed to better understand the associated correlates and inform effective interventions for enhanced medication adherence.

Keywords: medication adherence; heart; lung; thoracic; transplant (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2025
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