Photoirradiation of Polycyclic Aromatic Hydrocarbons with UVA Light – A Pathway Leading to the Generation of Reactive Oxygen Species, Lipid Peroxidation, and DNA Damage

Hongtao Yu, Qingsu Xia, Jian Yan, Diogenes Herreno-Saenz, Yuh-Shen Wu, I-Wah Tang and Peter P. Fu
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Hongtao Yu: Department of Chemistry, Jackson State University, Jackson, MS 39217, USA
Qingsu Xia: National Center for Toxicological Research, Jefferson, AR 72079, USA
Jian Yan: Department of Chemistry, Jackson State University, Jackson, MS 39217, USA
Diogenes Herreno-Saenz: Department of Pharmacology and Toxicology, School of Medicine, University of Puerto Rico, San Juan, Puerto Rico 00935
Yuh-Shen Wu: Hung Kuang University, Sha-Lu, Taichung, Taiwan, ROC
I-Wah Tang: National Center for Toxicological Research, Jefferson, AR 72079, USA
Peter P. Fu: National Center for Toxicological Research, Jefferson, AR 72079, USA

IJERPH, 2006, vol. 3, issue 4, 1-7

Abstract: Polycyclic aromatic hydrocarbons (PAHs) are a class of genotoxic environmental contaminants. We have long been interested in determining the mechanisms by which PAHs induce genotoxicity. Although the metabolic activation of PAHs leading to biological activities has been well studied, the photo-induced activation pathway has seldom reported. In this paper, we review the study of photoirradiation of PAHs with UVA irradiation results in (i) cytotoxicity and DNA damage (ii) DNA single strand cleavage; (iii) formation of 8-hydroxy-2’-deoxyguanosine adduct (8-OHdG), and (iv) formation of lipid peroxidation. Evidence has been shown that these photobiological activities are mediated by reactive oxygen species (ROS).

Keywords: Polycyclic aromatic hydrocarbons (PAHs); photoirradiation; lipid peroxidation; DNA damage; 8-OHdG (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2006
References: View complete reference list from CitEc
Citations: View citations in EconPapers (2)

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