Effect of Arsenic and Chromium on the Serum Amino-Transferases Activity in Indian Major Carp, Labeo rohita

Sesha Srinivas Vutukuru, N. Arun Prabhath, M. Raghavender and Anjaneyulu Yerramilli
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Sesha Srinivas Vutukuru: Environmental and Molecular Toxicology Laboratory, Centre for Environment, Institute of Science and Technology, Jawaharlal Nehru Technological University, Kukatpally, Hyderabad-500 072, India
N. Arun Prabhath: Environmental and Molecular Toxicology Laboratory, Centre for Environment, Institute of Science and Technology, Jawaharlal Nehru Technological University, Kukatpally, Hyderabad-500 072, India
M. Raghavender: Environmental and Molecular Toxicology Laboratory, Centre for Environment, Institute of Science and Technology, Jawaharlal Nehru Technological University, Kukatpally, Hyderabad-500 072, India
Anjaneyulu Yerramilli: Director, Trent Lott Geospatial and Visualization Centre, Visiting Professor Environmental Science and Chemistry, Jackson State University, Jackson, MS 39217-0939, USA

IJERPH, 2007, vol. 4, issue 3, 1-4

Abstract: Arsenic and hexavalent chromium toxicity results from their ability to interact with sulfahydryl groups of proteins and enzymes, and to substitute phosphorus in a variety of biochemical reactions. Alanine aminotransferase (ALT; E.C: 2.6.1.2) and Aspartate amino transferase (AST; EC 2.6.1.1) play a crucial role in transamination reactions and can be used as potential biomarkers to indicate hepatotoxicity and cellular damage. While histopathological studies in liver tissue require more time and expertise, simple and reliable biochemical analysis of ALT and AST can be used for a rapid assessment of tissue and cellular damage within 96 h. The main objective of this study was to determine the acute effects of arsenic and hexavalent chromium on the activity of ALT and AST in the Indian major carp, Labeo rohita for 24 h and 96 h. Significant increase in the activity of ALT (P Labeo rohita .

Keywords: Arsenic; chromium; acute toxicity; Labeo rohita; serum aminotransferase; biomarkers (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2007
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