Effects of ?-Tocopherol on Oxidative Status and Metabolic Profile in Overweight Women

J. L. Ble-Castillo, G. Cleva-Villanueva, J. C. Díaz-Zagoya, R. Medina-Santillán, H. O. Rubio-Arias and J. D. Méndez
Additional contact information
J. L. Ble-Castillo: General Hospital, Zone 46, IMSS, Prolongación de Avenida Universidad Km 2.5, Colonia Casa Blanca, 86060, Villahermosa, Tabasco, México
G. Cleva-Villanueva: Superior Medicine School of the National Polytechnic Institute, México, D.F., México
J. C. Díaz-Zagoya: Research Station in DACS, Juarez Autonomous University of Tabasco, Ave. Universidad No 2890, Colonia Tamulte, Villahermosa Tabasco, C.P. 86100, México
R. Medina-Santillán: Superior Medicine School of the National Polytechnic Institute, México, D.F., México
H. O. Rubio-Arias: Faculty of Medicine, National Autonomous University of Mexico, México D.F., México
J. D. Méndez: Hospital de Especialidades, CMN Siglo XXI, IMSS, Av. Cuauhtémoc 330, Col. Doctores 06725, México D.F., México

IJERPH, 2007, vol. 4, issue 4, 1-8

Abstract: Despite extensive research, the effects of ?-tocopherol supplementation remain controversial. Few studies have been focused on obese and overweight people. We examined the effects of ?-tocopherol (AT) on the oxidative status and metabolic profile in overweight women. Sixteen overweight women between the ages of 40-60 years old, received AT, 800 IU/day during 12 weeks, followed by a 6-week washout period. Blood samples were taken at the beginning and then every 6 weeks until the end of the study. AT, retinol, malondialdehyde (MDA), total antioxidant status (TAS), selenium-dependent glutathione peroxidase (GPx) and CuZn-superoxide dismutase (SOD) were quantified to evaluate the oxidative stress. The metabolic profile was estimated by measuring glycated hemoglobin (HbA1c) in erythrocytes and glucose, phosphate, magnesium, lipid and lipoprotein concentrations in serum. Under AT administration HbA1c, serum- MDA levels and erythrocyte GPx activity were markedly reduced. TAS, AT and Mg 2+ concentrations in serum and SOD activity in erythrocytes were higher after AT treatment. Body weight; glucose, lipid and retinol concentrations, or blood cells count were unchanged. Lipid peroxidation was considerably reduced in AT treated women and also improved serum antioxidant status was observed, but the imbalanced response between erythrocyte SOD and GPx activities could affect normal response to oxidative stress.

Keywords: ?-tocopherol; oxidative stress; lipid peroxidation; overweight (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2007
References: View complete reference list from CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.mdpi.com/1660-4601/4/4/260/pdf (application/pdf)
https://www.mdpi.com/1660-4601/4/4/260/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:4:y:2007:i:4:p:260-267:d:2353

Access Statistics for this article

IJERPH is currently edited by Ms. Jenna Liu

More articles in IJERPH from MDPI
Bibliographic data for series maintained by MDPI Indexing Manager ().