Effects of Benzo(a)pyrene on Intra-testicular Function in F-344 Rats

Anthony E. Archibong, Aramandla Ramesh, Mohammad S. Niaz, Cynthia M. Brooks, Shannon I. Roberson and Donald D. Lunstra
Additional contact information
Anthony E. Archibong: Department of Obstetrics & Gynecology, Meharry Medical College, Nashville, TN 37208, USA
Aramandla Ramesh: Department of Cancer Biology, Meharry Medical College, Nashville, TN 37208, USA
Mohammad S. Niaz: Department of Obstetrics & Gynecology, Meharry Medical College, Nashville, TN 37208, USA
Cynthia M. Brooks: Department of Obstetrics & Gynecology, Meharry Medical College, Nashville, TN 37208, USA
Shannon I. Roberson: Department of Obstetrics & Gynecology, Meharry Medical College, Nashville, TN 37208, USA
Donald D. Lunstra: U.S. Meat Animal Research Center, USDA, ARS, Clay Center, NE, 68933, USA

IJERPH, 2008, vol. 5, issue 1, 1-9

Abstract: The objective of this study was to evaluate the reproductive risk associated with exposure of adult male Fisher-344 (F-344) rats to inhaled benzo(a)pyrene (BaP), a ubiquitous environmental toxicant present in cigarette smoke, automobile exhaust fumes and industrial emissions. Rats were assigned randomly to a treatment or control group. Treatment consisted of exposure of rats via nose-only inhalation to 75?g BaP/m 3 , 4 hours daily for 60 days, while control animals were unexposed (UNC). Blood samples were collected immediately on day 60 of exposures (time 0) and subsequently at 24, 48, and 72 hours, to assess the effect of exposures to BaP on plasma testosterone and luteinizing hormone (LH) concentrations. Mean testis weight, total weight of tubules and total tubular length per paired testes were reduced 33% (P

Keywords: Benzo(a)pyrene; inhalation; testis; luteinizing hormone; testosterone; sperm production; rats (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2008
References: View complete reference list from CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.mdpi.com/1660-4601/5/1/32/pdf (application/pdf)
https://www.mdpi.com/1660-4601/5/1/32/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:5:y:2008:i:1:p:32-40:d:2292

Access Statistics for this article

IJERPH is currently edited by Ms. Jenna Liu

More articles in IJERPH from MDPI
Bibliographic data for series maintained by MDPI Indexing Manager ().