Effect of Garlic ( Allium sativum ) on Heavy Metal (Nickel II and ChromiumVI) Induced Alteration of Serum Lipid Profile in Male Albino Rats

Amrita Das Gupta, Swastika N. Das, Salim A. Dhundasi and Kusal K. Das
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Amrita Das Gupta: Environmental Health Research Unit, Department of Physiology, Al Ameen Medical College, Bijapur 586108 Karnataka, India
Swastika N. Das: Department of Engineering Chemistry, B.L.D.E.A’s. Dr. P. G. Halakatti College of Engineering and Technology, Bijapur, India
Salim A. Dhundasi: Environmental Health Research Unit, Department of Physiology, Al Ameen Medical College, Bijapur 586108 Karnataka, India
Kusal K. Das: Environmental Health Research Unit, Department of Physiology, Al Ameen Medical College, Bijapur 586108 Karnataka, India

IJERPH, 2008, vol. 5, issue 3, 1-5

Abstract: We have studied the effect of simultaneous oral treatment of aqueous garlic extract ( Allium sativum ) on heavy metal (nickel II and chromium VI) induced changes in serum lipid profile. Nickel sulfate and potassium dichromate treated rats showed a significant increase in serum low density lipoprotein-cholesterol (LDL-C), very low density lipoprotein-cholesterol (VLDL-C) and triglyceride (TG) level as well as decrease in serum high density lipoprotein-cholesterol (HDL-C) level. Simultaneous garlic administration with nickel sulfate showed improvement in serum LDL-C, HDL-C, VLDL-C and TG level. But in case of potassium dichromate, garlic administration did not show satisfactory improvement in lipid profile except VLDL-C and TG level. The results indicate that garlic ( Allium sativum ) has some beneficial effect in preventing heavy metal (nickel and chromium VI) induced alteration of lipid profile.

Keywords: Garlic (Allium sativum); nickel sulfate; potassium dichromate; serum lipid profile (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2008
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