Preclinical Assessment of Vernonia amygdalina Leaf Extracts as DNA Damaging Anti-cancer Agent in the Management of Breast Cancer

Clement Yedjou, Ernest Izevbigie and Paul B. Tchounwou
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Clement Yedjou: Cellomics and Toxicogenomics Research Laboratory, NIH-RCMI Center for Environmental Health, 1400 Lynch Street, P.O. Box 18540, Jackson, MS, USA
Ernest Izevbigie: Cellular Signalling, Phytoceuticals, Cancer Prevention and Therapies, College of Science, Engineering and Technology, Jackson State University, 1400 Lynch Street, P.O. Box 18540, Jackson, Mississippi, USA
Paul B. Tchounwou: Cellomics and Toxicogenomics Research Laboratory, NIH-RCMI Center for Environmental Health, 1400 Lynch Street, P.O. Box 18540, Jackson, MS, USA

IJERPH, 2008, vol. 5, issue 5, 1-5

Abstract: Breast cancer is the leading cause of death among women between 40 and 55 years of age and is the second overall cause of death among women. Fortunately, the mortality rate from breast cancer has decreased in recent years due to an increased emphasis on early detection and more effective treatments. Despite early detection, conventional and chemotherapeutic methods of treatment, about 7% of women still died every year. Hence, the aim of the present study was to assess the therapeutic efficacy of Vernonia amygdalina (VA) leaf extracts as anti-cancer agent against human breast cancer in vitro using the MTT [3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] and alkaline single cell gel electrophoresis (Comet) assays, respectively. In this experiment, human breast adenocarcinoma (MCF-7) cells were treated with different doses of VA leaf extracts for 48 hours. Data obtained from the MTT assay showed that VA significantly ((P

Keywords: Vernonia amygdalina; MCF-7 cells; cytotoxicity; genotoxicity; DNA damage (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2008
References: View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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