Vernonia amygdalina: Anticancer Activity, Authentication, and Adulteration Detection

Lecia J. Gresham, Jetaime Ross and Ernest B. Izevbigie
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Lecia J. Gresham: The Laboratory of Cellular Signaling, Phytoceuticals, and Cancer Prevention and Therapies; College of Science, Engineering and Technology, Jackson State University, Jackson, MS 39217, USA
Jetaime Ross: The Laboratory of Cellular Signaling, Phytoceuticals, and Cancer Prevention and Therapies; College of Science, Engineering and Technology, Jackson State University, Jackson, MS 39217, USA
Ernest B. Izevbigie: The Laboratory of Cellular Signaling, Phytoceuticals, and Cancer Prevention and Therapies; College of Science, Engineering and Technology, Jackson State University, Jackson, MS 39217, USA

IJERPH, 2008, vol. 5, issue 5, 1-7

Abstract: Evidence suggests that most chemotherapeutic agents are less effective as treatment in patients with estrogen receptor-negative (ER-) breast carcinomas compared to those with estrogen receptor-positive (ER+) breast carcinomas. Moreover, African American Women (AAW) is disproportionately diagnosed with ER- breast cancer compared to their white counterparts. Novel therapies effective against ER- breast carcinomas are urgently needed to ameliorate the health disparity. Previous reports show that low concentrations (microgram/ml) of water-soluble leaf extracts of a Nigerian edible plant, V. amygdalina (VA), potently retards the proliferative activities of ER+ human breast cancerous cells (MCF-7) in vitro in a concentration-dependent fashion. However, the anti-proliferative activities of VA in either ductal or ER- carcinoma cells have not been characterized. The exposure of BT-549 to increasing concentrations of VA (10, 100, and 1000 µg/mL) inhibited cell growth by approximately 14% (P

Keywords: anti-cancer; vernonia amygdalina; activity prediction; standardization (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2008
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