A History of Alcohol Dependence Increases the Incidence and Severity of Postoperative Cognitive Dysfunction in Cardiac Surgical Patients

Judith A. Hudetz, Kathleen M. Patterson, Alison J. Byrne, Zafar Iqbal, Sweeta D. Gandhi, David C. Warltier and Paul S. Pagel
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Judith A. Hudetz: Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Kathleen M. Patterson: Clement J. Zablocki Veterans Administration Medical Center, Milwaukee, WI 53295, USA
Alison J. Byrne: Clement J. Zablocki Veterans Administration Medical Center, Milwaukee, WI 53295, USA
Zafar Iqbal: Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Sweeta D. Gandhi: Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
David C. Warltier: Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Paul S. Pagel: Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA

IJERPH, 2009, vol. 6, issue 11, 1-15

Abstract: Postoperative cognitive dysfunction (POCD) commonly occurs after cardiac surgery. We tested the hypothesis that a history of alcohol dependence is associated with an increased incidence and severity of POCD in male patients undergoing cardiac surgery using cardiopulmonary bypass. Recent verbal and nonverbal memory and executive functions were assessed before and one week after surgery in patients with or without a history of alcohol dependence. Cognitive function was significantly reduced after cardiac surgery in patients with versus without a history of alcohol dependence. The results suggest that a history of alcohol dependence increases the incidence and severity of POCD after cardiac surgery.

Keywords: alcohol dependence; cardiac surgery; cardiopulmonary bypass; neurocognitive function (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2009
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