Chronic Stress and the Development of Early Atherosclerosis: Moderating Effect of Endothelial Dysfunction and Impaired Arterial Elasticity

Nadja Chumaeva, Mirka Hintsanen, Niklas Ravaja, Markus Juonala, Olli T. Raitakari and Liisa Keltikangas-Järvinen
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Nadja Chumaeva: Department of Psychology, University of Helsinki, P.O. Box 9, 00014 Helsinki, Finland
Mirka Hintsanen: Department of Psychology, University of Helsinki, P.O. Box 9, 00014 Helsinki, Finland
Niklas Ravaja: Center for Knowledge and Innovation Research, Helsinki School of Economics, P.O. Box 1210, 00101 Helsinki, Finland
Markus Juonala: Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Kiinanmyllynkatu 10, 20520 Turku, Finland
Olli T. Raitakari: Department of Clinical Physiology, University of Turku, P.O. Box 52, 20521 Turku, Finland
Liisa Keltikangas-Järvinen: Department of Psychology, University of Helsinki, P.O. Box 9, 00014 Helsinki, Finland

IJERPH, 2009, vol. 6, issue 12, 1-16

Abstract: This study aims to explore the interactive effect of vital exhaustion (VE) and endothelial dysfunction on preclinical atherosclerosis, assessed by carotid intima-media thickness (IMT). Furthermore, interaction between VE and carotid elasticity is examined. Participants were 1,596 young healthy adults from the Cardiovascular Risk in Young Finns study. Endothelial dysfunction was measured by brachial flow-mediated dilatation (FMD), and carotid elasticity by carotid artery compliance (CAC). Significant interactions between FMD and VE, and between CAC and VE, for IMT were found in participants with the very lowest FMD and CAC. Thus, VE may be harmful if the endothelium is not working properly.

Keywords: chronic stress; vital exhaustion; intima-media thickness; flow-mediated dilatation; carotid artery compliance; atherosclerosis (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2009
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