Association between a Polymorphism of Aminolevulinate Dehydrogenase (ALAD) Gene and Blood Lead Levels in Japanese Subjects

Koichi Miyaki, Htay Lwin, Katsunori Masaki, Yixuan Song, Yoshimitsu Takahashi, Masaaki Muramatsu and Takeo Nakayama
Additional contact information
Koichi Miyaki: Department of Neurology, School of Medicine, Keio University, Tokyo, Japan
Htay Lwin: Department of Neurology, School of Medicine, Keio University, Tokyo, Japan
Katsunori Masaki: Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
Yixuan Song: Department of Molecular Epidemiology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
Yoshimitsu Takahashi: Department of Health Informatics, School of Public Health, Graduate School of Medicine, Kyoto University, Kyoto, Japan
Masaaki Muramatsu: Department of Molecular Epidemiology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
Takeo Nakayama: Department of Health Informatics, School of Public Health, Graduate School of Medicine, Kyoto University, Kyoto, Japan

IJERPH, 2009, vol. 6, issue 3, 1-11

Abstract: This cross-sectional study investigated the relationship between the aminolevulinate dehydrogenase (ALAD) genotype and blood lead levels among 101 Japanese workers. Blood lead concentration measurement, biomarkers, and genotyping were performed. The minor allele frequency (MAF) for ALAD (ALAD2) was 0.08. Although the blood lead level in the subjects with heterozygous GC genotype was significantly higher than those with homozygous GG genotype, there were no significant differences for hemoglobin, hematocrit, serum and urinary ALA levels among genotypes. ALAD2 genotype was significantly associated with the blood lead concentration, even in the environmental lead exposed subjects. Further confirmation with a large sample size is needed.

Keywords: ALAD gene; blood lead level; environmentally lead exposure; Japanese (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2009
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (2)

Downloads: (external link)
https://www.mdpi.com/1660-4601/6/3/999/pdf (application/pdf)
https://www.mdpi.com/1660-4601/6/3/999/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:6:y:2009:i:3:p:999-1009:d:4210

Access Statistics for this article

IJERPH is currently edited by Ms. Jenna Liu

More articles in IJERPH from MDPI
Bibliographic data for series maintained by MDPI Indexing Manager ().