The Effect of Uncertainty in Exposure Estimation on the Exposure-Response Relation between 1,3-Butadiene and Leukemia

John J. Graff, Nalini Sathiakumar, Maurizio Macaluso, George Maldonado, Robert Matthews and Elizabeth Delzell
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John J. Graff: Wayne State University School of Medicine, Karmanos Cancer Institute, Detroit, MI 48201, USA
Nalini Sathiakumar: University of Alabama at Birmingham School of Public Health, Department of Epidemiology, Birmingham, AL 35294, USA
Maurizio Macaluso: University of Alabama at Birmingham School of Public Health, Department of Epidemiology, Birmingham, AL 35294, USA
George Maldonado: University of Minnesota School of Public Health, Division of Environmental Health Sciences, Minneapolis, MN 55455, USA
Robert Matthews: University of Alabama at Birmingham School of Public Health, Department of Epidemiology, Birmingham, AL 35294, USA
Elizabeth Delzell: University of Alabama at Birmingham School of Public Health, Department of Epidemiology, Birmingham, AL 35294, USA

IJERPH, 2009, vol. 6, issue 9, 1-20

Abstract: Abstract: In a follow-up study of mortality among North American synthetic rubber industry workers, cumulative exposure to 1,3-butadiene was positively associated with leukemia. Problems with historical exposure estimation, however, may have distorted the association. To evaluate the impact of potential inaccuracies in exposure estimation, we conducted uncertainty analyses of the relation between cumulative exposure to butadiene and leukemia. We created the 1,000 sets of butadiene estimates using job-exposure matrices consisting of exposure values that corresponded to randomly selected percentiles of the approximate probability distribution of plant-, work area/job group-, and year specific butadiene ppm. We then analyzed the relation between cumulative exposure to butadiene and leukemia for each of the 1,000 sets of butadiene estimates. In the uncertainty analysis, the point estimate of the RR for the first non zero exposure category (>0–

Keywords: 1,3-butadiene; epidemiology; methods; leukemia; workplace exposures; uncertainty analysis (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2009
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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