Potential Risk Factors for Cutaneous Squamous Cell Carcinoma include Oral Contraceptives: Results of a Nested Case-Control Study

Maryam M. Asgari, Jimmy T. Efird, E. Margaret Warton and Gary D. Friedman
Additional contact information
Maryam M. Asgari: Division of Research, Kaiser Permanente Northern California, Oakland, CA 94612, USA
Jimmy T. Efird: Center for Health of Vulnerable Populations, Office of the Dean, School of Nursing, University of North Carolina, Greensboro, NC 27402, USA
E. Margaret Warton: Division of Research, Kaiser Permanente Northern California, Oakland, CA 94612, USA
Gary D. Friedman: Division of Research, Kaiser Permanente Northern California, Oakland, CA 94612, USA

IJERPH, 2010, vol. 7, issue 2, 1-16

Abstract: Recently, a population-based case-control study observed a 60% increased odds ratio (OR) for cutaneous squamous cell carcinoma (SCC) among women who had ever used oral contraceptives (OCs) compared with non users (95% confidence interval (CI) = 1.0–2.5). To further characterize the putative association between OC use and SCC risk, we conducted a nested case-control study using a large retrospective cohort of 111,521 Kaiser Permanente Northern California members. Multivariable conditional logistic regression was used to estimate ORs and CIs adjusting for known and hypothesized SCC risk factors. Pre-diagnostic OC use was associated with a statistically significant increased OR for SCC in univariate analysis (OR = 2.4, CI = 1.2–4.8), with borderline statistical significance in multivariable analysis (CI = 2.0, CI = 0.91–4.5). Given the high incidence of SCC in the general population and the prevalent use of OCs among women in the United States, there is a need for more large, carefully designed epidemiologic studies to determine whether the observed association between OC use and SCC can be replicated and to better understand the etiologic basis of an association if one exists.

Keywords: squamous cell carcinoma; oral contraceptives; risk factors; epidemiology (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2010
References: View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.mdpi.com/1660-4601/7/2/427/pdf (application/pdf)
https://www.mdpi.com/1660-4601/7/2/427/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:7:y:2010:i:2:p:427-442:d:7051

Access Statistics for this article

IJERPH is currently edited by Ms. Jenna Liu

More articles in IJERPH from MDPI
Bibliographic data for series maintained by MDPI Indexing Manager ().