Maternal Diet, Behaviour and Offspring Skeletal Health

Laura R. Goodfellow, Susannah Earl, Cyrus Cooper and Nicholas C. Harvey
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Laura R. Goodfellow: Medical Research Council Epidemiology Resource Centre, University of Southampton School of Medicine, Southampton General Hospital, Southampton SO16 6YD, UK
Susannah Earl: Medical Research Council Epidemiology Resource Centre, University of Southampton School of Medicine, Southampton General Hospital, Southampton SO16 6YD, UK
Cyrus Cooper: Medical Research Council Epidemiology Resource Centre, University of Southampton School of Medicine, Southampton General Hospital, Southampton SO16 6YD, UK
Nicholas C. Harvey: Medical Research Council Epidemiology Resource Centre, University of Southampton School of Medicine, Southampton General Hospital, Southampton SO16 6YD, UK

IJERPH, 2010, vol. 7, issue 4, 1-13

Abstract: Osteoporotic fracture has a major impact upon health, both in terms of acute and long term disability and economic cost. Peak bone mass, achieved in early adulthood, is a major determinant of osteoporosis risk in later life. Poor early growth predicts reduced bone mass, and so risk of fracture in later life. Maternal lifestyle, body build and 25(OH) vitamin D status predict offspring bone mass. Recent work has suggested epigenetic mechanisms as key to these observations. This review will explore the role of the early environment in determining later osteoporotic fracture risk.

Keywords: osteoporosis; epigenetic; early life origins; fracture; bone mass; vitamin D; neonate; fetus (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2010
References: View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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