Assessment of Benzo(a)pyrene-equivalent Carcinogenicity and Mutagenicity of Residential Indoor versus Outdoor Polycyclic Aromatic Hydrocarbons Exposing Young Children in New York City

Kyung Hwa Jung, Beizhan Yan, Steven N. Chillrud, Frederica P. Perera, Robin Whyatt, David Camann, Patrick L. Kinney and Rachel L. Miller
Additional contact information
Kyung Hwa Jung: Division of Pulmonary, Allergy and Critical Care of Medicine, College of Physicians and Surgeons, Columbia University, PH8E, 630 W. 168 St. New York, NY 10032, USA
Beizhan Yan: Lamont-Doherty Earth Observatory, Columbia University, 61 Rt, 9W Palisades, NY 10964, USA
Steven N. Chillrud: Lamont-Doherty Earth Observatory, Columbia University, 61 Rt, 9W Palisades, NY 10964, USA
Frederica P. Perera: Mailman School of Public Health, Department of Environmental Health Sciences, Columbia University, 60 Haven Ave., B-1 New York, NY 10032, USA
Robin Whyatt: Mailman School of Public Health, Department of Environmental Health Sciences, Columbia University, 60 Haven Ave., B-1 New York, NY 10032, USA
David Camann: Southwest Research Institute, 6220 Culebra Road, San Antonio, TX 78228, USA
Patrick L. Kinney: Mailman School of Public Health, Department of Environmental Health Sciences, Columbia University, 60 Haven Ave., B-1 New York, NY 10032, USA
Rachel L. Miller: Division of Pulmonary, Allergy and Critical Care of Medicine, College of Physicians and Surgeons, Columbia University, PH8E, 630 W. 168 St. New York, NY 10032, USA

IJERPH, 2010, vol. 7, issue 5, 1-12

Abstract: The application of benzo(a)pyrene (BaP)-toxic equivalent factor to polycyclic aromatic hydrocarbons (PAH) concentrations can provide a more accurate risk assessment from environmental exposure to PAH. We hypothesized that BaP-equivalent toxicity determined following residential air monitoring among young urban children may vary by season. Residential indoor and outdoor air levels of PAH measured over two-weeks in a cohort of 5–6 year old children (n = 260) in New York City were normalized to the cancer and mutagen potency equivalent factor of BaP (BaP = 1). Data are presented as carcinogenic equivalents (BaP-TEQ) and mutagenic equivalents (BaP-MEQ) for the sum of 8 PAH (? 8 PAH; MW ³ 228) and individual PAH and compared across heating versus nonheating seasons. Results show that heating compared to nonheating season was associated significantly with higher (BaP-TEQ) ?8PAH and (BaP-MEQ) ?8PAH both indoors and outdoors (p ?8PAH and (BaP-MEQ) ?8PAH were significantly higher than the corresponding indoor measures during the heating season (p

Keywords: risk assessment; PAH; BaP-equivalents; TEF; MEF; heating season; indoor; outdoor; and children (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2010
References: View complete reference list from CitEc
Citations: View citations in EconPapers (4)

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