Perinatal Bisphenol A Exposure in C57B6/129svj Male Mice: Potential Altered Cytokine/Chemokine Production in Adulthood

Steven D. Holladay, Shuo Xiao, Honglu Diao, Jamie Barber, Tomas Nagy, Xiaoqin Ye and Robert M. Gogal
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Steven D. Holladay: Department of Anatomy and Radiology, College of Veterinary Medicine, University of Georgia, Athens, Georgia, GA 30602, USA
Shuo Xiao: Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens, Georgia, GA 30602, USA
Honglu Diao: Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens, Georgia, GA 30602, USA
Jamie Barber: Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, Georgia, GA 30602, USA
Tomas Nagy: Pathology, College of Veterinary Medicine, University of Georgia, Athens, Georgia, GA 30602, USA
Xiaoqin Ye: Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens, Georgia, GA 30602, USA
Robert M. Gogal: Department of Anatomy and Radiology, College of Veterinary Medicine, University of Georgia, Athens, Georgia, GA 30602, USA

IJERPH, 2010, vol. 7, issue 7, 1-8

Abstract: Pregnant mice (n = 3) were exposed to BPA by intraperitoneal injection, from gestation day 9.5 until end of lactation. Male offspring were evaluated for cytokine production at 20 wk-of-age. One pregnant control mouse produced no males, precluding statistical analysis. However, recurring shifts in cytokines were suggested in the adult BPA offspring. Serum showed a numeric increase in 16 of 21 basal cytokine levels. ConA-stimulated splenocytes showed a numeric increase in 17 of 21 cytokines, and LPS-stimulated splenocytes an increase in 18 of 21 cytokines. The cytokine profile was one of T H 1 up-regulation more than T H 2, and with skewing toward T H 17 responses.

Keywords: bisphenol; developmental; cytokines; immune (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2010
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