Clinical, Radiological, and Pathological Investigation of Asbestosis

Takumi Kishimoto, Katsuya Kato, Hiroaki Arakawa, Kazuto Ashizawa, Kouki Inai and Yukio Takeshima
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Takumi Kishimoto: Asbestos Research Center, Okayama Rosai Hospital, 1-10-25 Chikkomidorimachi, Minamiku Okayama City, 702-8055, Japan
Katsuya Kato: Department of Radiology, Okayama University School of Medicine, 2-5-1,Shikata-cho, Kitaku, Okayama City, 702-8558, Japan
Hiroaki Arakawa: Department of Radiology, Dokkyo Medical University, 880, Kitakobayashi, Mibumati, Shimotuga-gun, Tochigi City, 321-0293, Japan
Kazuto Ashizawa: Department of Radiology, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki City, 852-8501, Japan
Kouki Inai: Department of Pathology, Hiroshima University School of Medicine, 1-2-3 Kasumi, Minamiku, Hiroshima City, 734-0037, Japan
Yukio Takeshima: Department of Pathology, Hiroshima University School of Medicine, 1-2-3 Kasumi, Minamiku, Hiroshima City, 734-0037, Japan

IJERPH, 2011, vol. 8, issue 3, 1-14

Abstract: By the radiological examination, differential diagnosis of asbestosis from chronic interstitial pneumonia such as IPF/UIP is difficult. The pathological features of asbestosis show the peribronchiolar fibrosis which suggest that asbestos fibers cause the inflammation of bronchioli. Therefore, the criteria for pathological diagnosis of asbestosis in 2010, contain the finding of peribronchiolar fibrosis again. Chest CT scanning including HRCT for total of 38 cases clinically diagnosed asbestosis were reviewed by 3 radiologists and one pulmonologist. On the other hand, the histology of lung tissues obtained by surgery or autopsy were examined by 4 pulmonological pathologists. Furthermore, the content of asbestos bodies in the lung was counted by phase-contrast microscopy. Thirteen cases were definitely diagnosed of asbestosis in the image including HRCT and 17 cases were diagnosed by the histopathological examination showing lung fibrosis with peribronchiolar fibrosis. Only 10 cases were indicated asbestosis by both the radiological and histopathological examinations. The mean value of asbestos bodies for these cases, was 2,133,255 per gram of dry lung tissue.

Keywords: asbestosis; peribronchiolar fibrosis; IPF/UIF; asbestos body (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2011
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