Nanoparticles and Colloids as Contributing Factors in Neurodegenerative Disease

Stephen C. Bondy
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Stephen C. Bondy: Division of Occupational & Environmental Health, Department of Medicine, University of California, Irvine, Irvine, CA 92697, USA

IJERPH, 2011, vol. 8, issue 6, 1-12

Abstract: This review explores the processes underlying the deleterious effects of the presence of insoluble or colloidal depositions within the central nervous system. These materials are chemically unreactive and can have a prolonged residence in the brain. They can be composed of mineral or proteinaceous materials of intrinsic or exogenous origin. Such nanoparticulates and colloids are associated with a range of slow-progressing neurodegenerative states. The potential common basis of toxicity of these materials is discussed. A shared feature of these disorders involves the appearance of deleterious inflammatory changes in the CNS. This may be due to extended and ineffective immune responses. Another aspect is the presence of excess levels of reactive oxygen species within the brain. In addition with their induction by inflammatory events, these may be further heightened by the presence of redox active transition metals to the large surface area afforded by nanoparticles and amphipathic micelles.

Keywords: nanoparticles; colloids; neuroinflammation; neurodegenerative disease; immune system (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2011
References: View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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