Protective Effect of Anthocyanins from Lingonberry on Radiation-induced Damages

Zi-Luan Fan, Zhen-Yu Wang, Li-Li Zuo and Shuang-Qi Tian
Additional contact information
Zi-Luan Fan: School of Forestry, Northeast Forestry University, 26 HeXing Road, XiangFang District, Harbin 150040, China
Zhen-Yu Wang: School of Forestry, Northeast Forestry University, 26 HeXing Road, XiangFang District, Harbin 150040, China
Li-Li Zuo: School of Food Science and Engineering, Harbin Institute of Technology, 73 HuangHe Road, NanGang District, Harbin 150090, China
Shuang-Qi Tian: College of Food Science and Technology, Henan University of Technology, Zhengzhou 450001, China

IJERPH, 2012, vol. 9, issue 12, 1-12

Abstract: There is a growing concern about the serious harm of radioactive materials, which are widely used in energy production, scientific research, medicine, industry and other areas. In recent years, owing to the great side effects of anti-radiation drugs, research on the radiation protectants has gradually expanded from the previous chemicals to the use of natural anti-radiation drugs and functional foods. Some reports have confirmed that anthocyanins are good antioxidants, which can effectively eliminate free radicals, but studies on the immunoregulatory and anti-radiation effects of anthocyanins from lingonberry (ALB) are less reported. In this experiment, mice were given orally once daily for 14 consecutive days before exposure to 6 Gy of gamma-radiation and were sacrificed on the 7th day post-irradiation. The results showed that the selected dose of extract did not lead to acute toxicity in mice; while groups given anthocyanins orally were significantly better than radiation control group according to blood analysis; pretreatment of anthocyanins significantly ( p < 0.05) enhanced the thymus and spleen indices and spleen cell survival compared to the irradiation control group. Pretreatment with anthocyanins before irradiation significantly reduced the numbers of micronuclei (MN) in bone marrow polychromatic erythrocytes (PCEs). These findings indicate that anthocyanins have immunostimulatory potential against immunosuppression induced by the radiation.

Keywords: lingonberry; anthocyanins; radioprotection; immunomodulatory (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2012
References: View complete reference list from CitEc
Citations: View citations in EconPapers (2)

Downloads: (external link)
https://www.mdpi.com/1660-4601/9/12/4732/pdf (application/pdf)
https://www.mdpi.com/1660-4601/9/12/4732/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:9:y:2012:i:12:p:4732-4743:d:22279

Access Statistics for this article

IJERPH is currently edited by Ms. Jenna Liu

More articles in IJERPH from MDPI
Bibliographic data for series maintained by MDPI Indexing Manager ().