Malignant Transformation of Rat Kidney Induced by Environmental Substances and Estrogen

Susana Alfaro-Lira, María Pizarro-Ortiz and Gloria M. Calaf
Additional contact information
Susana Alfaro-Lira: Instituto de Alta Investigación, Universidad de Tarapacá, Calle Antofagasta 1520, Arica, Chile
María Pizarro-Ortiz: Instituto de Alta Investigación, Universidad de Tarapacá, Calle Antofagasta 1520, Arica, Chile
Gloria M. Calaf: Instituto de Alta Investigación, Universidad de Tarapacá, Calle Antofagasta 1520, Arica, Chile

IJERPH, 2012, vol. 9, issue 5, 1-19

Abstract: The use of organophosphorous insecticides in agricultural environments and in urban settings has increased significantly. The aim of the present study was to analyze morphological alterations induced by malathion and 17?-estradiol (estrogen) in rat kidney tissues. There were four groups of animals: control, malathion, estrogen and combination of both substances. The animals were injected for five days and sacrificed 30, 124 and 240 days after treatments. Kidney tissues were analyzed for histomorphological and immunocytochemical alterations. Morphometric analysis indicated that malathion plus estrogen-treated animals showed a significantly ( p

Keywords: estrogen; malathion; kidney; atypical cell proliferation; MFG; ER-?; ER-?; PgR; CYP1A1; Neu/ErbB2; PCNA; vimentin; THBS (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2012
References: View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.mdpi.com/1660-4601/9/5/1630/pdf (application/pdf)
https://www.mdpi.com/1660-4601/9/5/1630/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:9:y:2012:i:5:p:1630-1648:d:17552

Access Statistics for this article

IJERPH is currently edited by Ms. Jenna Liu

More articles in IJERPH from MDPI
Bibliographic data for series maintained by MDPI Indexing Manager ().