Genotoxicity of Silver Nanoparticles in Vicia faba: A Pilot Study on the Environmental Monitoring of Nanoparticles

Anita K. Patlolla, Ashley Berry, LaBethani May and Paul B. Tchounwou
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Anita K. Patlolla: Molecular Toxicology Research Laboratory, NIH-RCMI Center for Environmental Health, College of Science Engineering and Technology, Jackson State University, Jackson, MS 39217, USA
Ashley Berry: Molecular Toxicology Research Laboratory, NIH-RCMI Center for Environmental Health, College of Science Engineering and Technology, Jackson State University, Jackson, MS 39217, USA
LaBethani May: Molecular Toxicology Research Laboratory, NIH-RCMI Center for Environmental Health, College of Science Engineering and Technology, Jackson State University, Jackson, MS 39217, USA
Paul B. Tchounwou: Molecular Toxicology Research Laboratory, NIH-RCMI Center for Environmental Health, College of Science Engineering and Technology, Jackson State University, Jackson, MS 39217, USA

IJERPH, 2012, vol. 9, issue 5, 1-14

Abstract: The use of silver nanoparticles (AgNPs) in commercial products has increased significantly in recent years. Although there have been some attempts to determine the toxic effects of AgNPs in mammalian and human cell-lines, there is little information on plants which play a vital role in ecosystems. The study reports the use of Vicia faba root-tip meristem to investigate the genotoxicity of AgNPs under modified GENE-TOX test conditions. The root tip cells of V. faba were treated with four different concentrations of engineered AgNPs dispersion to study toxicological endpoints such as mitotic index (MI), chromosomal aberrations (CA) and micronucleus induction (MN). For each concentration, five sets of microscopy observations were carried out. The results demonstrated that AgNPs exposure significantly increased (p

Keywords: silver nanoparticles; chromosomal aberrations; mitotic index; Vicia faba; genotoxicity; micronucleus (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2012
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