Monoterpenoids: The Next Frontier in the Treatment of Chronic Pain?

Filomena Perri, Adriana Coricello and James D. Adams
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Filomena Perri: Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90089, USA
Adriana Coricello: Dipartimento di Scienze della Salute, Università “Magna Græcia” di Catanzaro, 88100 Catanzaro, Italy
James D. Adams: Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90089, USA

J, 2020, vol. 3, issue 2, 1-20

Abstract: Ointments and lotions from natural extracts have a long tradition of being used in folk medicines against pain conditions. Monoterpenoids are among the major constituents of several natural topical remedies. The field of chronic pain is one of the most investigated for new active molecular entities. This review will discuss several molecular mechanisms against which monoterpenoids have been proven to be good candidates for the topical treatment of chronic pain.

Keywords: monoterpenoids; pain chemokine cycle; interleukin-17; topical treatment; transient receptor potential (TRP) cation channels (search for similar items in EconPapers)
JEL-codes: I1 I10 I12 I13 I14 I18 I19 (search for similar items in EconPapers)
Date: 2020
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