Kupffer Cells as a Target for Immunotherapy

Takashi Sakai () and Wen-Ling Lin
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Takashi Sakai: Institute for Health Sciences, Tokushima Bunri University, 180 Nishihama-bouji, Yamashiro-cho, Tokushima 770-8514, Japan
Wen-Ling Lin: Graduate Institute of Metabolism and Obesity Sciences, Taipei Medical University, Taipei 110, Taiwan

J, 2022, vol. 5, issue 4, 1-6

Abstract: Kupffer cells (KCs) are resident macrophages in the liver. Recent studies have revealed that KCs are closely related to inflammatory liver diseases, including nonalcoholic liver diseases (NAFLD). From this point of view, KC transplantation can be a candidate for immunotherapy against inflammatory diseases. Similar to general macrophages, KCs show several different phenotypes according to their environment. Activated KCs are involved in either proinflammatory responses or anti-inflammatory responses. Thus, to manipulate KCs for immunotherapy, it is crucial to control the direction of KC activation. Here, we summarize the outlook and the issues hindering immunotherapy using KC transplantation.

Keywords: Kupffer cells; macrophages; hepatic stellate cells; immunotherapy; NAFLD (search for similar items in EconPapers)
JEL-codes: I1 I10 I12 I13 I14 I18 I19 (search for similar items in EconPapers)
Date: 2022
References: View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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