Mapping the Glymphatic Pathway Using Imaging Advances

Rajvi N. Thakkar, Ivelina P. Kioutchoukova, Ian Griffin, Devon T. Foster, Pratiksha Sharma, Eduardo Molina Valero and Brandon Lucke-Wold ()
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Rajvi N. Thakkar: College of Medicine, University of Florida, Gainesville, FL 32610, USA
Ivelina P. Kioutchoukova: College of Medicine, University of Florida, Gainesville, FL 32610, USA
Ian Griffin: College of Medicine, University of Florida, Gainesville, FL 32610, USA
Devon T. Foster: College of Medicine, Florida International University, Miami, FL 33199, USA
Pratiksha Sharma: Thermo Fisher Scientific Inc., Boston, MA 02210, USA
Eduardo Molina Valero: College of Medicine, University of Florida, Gainesville, FL 32610, USA
Brandon Lucke-Wold: Department of Neurosurgery, University of Florida, 1600 SW Archer Rd., Gainesville, FL 32610, USA

J, 2023, vol. 6, issue 3, 1-15

Abstract: The glymphatic system is a newly discovered waste-clearing system that is analogous to the lymphatic system in our central nervous system. Furthermore, disruption in the glymphatic system has also been associated with many neurodegenerative disorders (e.g., Alzheimer’s disease), traumatic brain injury, and subarachnoid hemorrhage. Thus, understanding the function and structure of this system can play a key role in researching the progression and prognoses of these diseases. In this review article, we discuss the current ways to map the glymphatic system and address the advances being made in preclinical mapping. As mentioned, the concept of the glymphatic system is relatively new, and thus, more research needs to be conducted in order to therapeutically intervene via this system.

Keywords: glymphatic system; magnetic resonance imaging (MRI) sequencing; imaging techniques; neurological diseases (search for similar items in EconPapers)
JEL-codes: I1 I10 I12 I13 I14 I18 I19 (search for similar items in EconPapers)
Date: 2023
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