Inflammatory Bowel Diseases in Spain: A View from the Present to the Future

Raquel Francés, Yuanji Fu, Christophe Desterke and Jorge Mata-Garrido ()
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Raquel Francés: Energy & Memory, Brain Plasticity Unit, CNRS, ESPCI Paris, PSL Research University, 75005 Paris, France
Yuanji Fu: INSERM, CNRS, Institut Necker Enfants Malades, Université Paris Cité, 75015 Paris, France
Christophe Desterke: Faculté de Médecine du Kremlin Bicêtre, Université Paris-Saclay, 94270 Le Kremlin-Bicêtre, France
Jorge Mata-Garrido: INSERM U993, Unité Organisation Nucléaire et Oncogenèse, Institut Pasteur, Université Paris Cité, 75015 Paris, France

J, 2024, vol. 7, issue 4, 1-13

Abstract: Inflammatory bowel disease (IBD), encompassing Crohn’s disease and ulcerative colitis, presents a growing health challenge in Spain. This review examines the current understanding of IBD through the lens of genetics, epigenetics, and metabolism, offering insights into future directions for research and clinical management. Recent advancements in genetic studies have identified numerous susceptibility loci, highlighting the complex interplay between genetic predisposition and environmental triggers. Epigenetic modifications, including DNA methylation and histone modification, further elucidate the pathogenesis of IBD, underscoring the role of gene–environment interactions. Metabolic alterations, particularly in the gut microbiome, emerge as crucial factors influencing disease onset and progression. The integration of multi-omics approaches has enhanced our comprehension of the molecular mechanisms underlying IBD, paving the way for personalized medicine. Looking forward, this review emphasizes the need for longitudinal studies and advanced bioinformatics tools to decode the intricate networks involved in IBD. Additionally, we discuss the potential of novel therapeutic strategies, including epigenetic drugs and microbiome modulation, as promising avenues for improved patient outcomes. This comprehensive overview provides a foundation for future research aimed at unraveling the complexities of IBD and developing innovative treatments tailored to the Spanish population.

Keywords: inflammatory bowel disease; Crohn’s disease; ulcerative colitis; epigenetics; microbiota; metabolism (search for similar items in EconPapers)
JEL-codes: I1 I10 I12 I13 I14 I18 I19 (search for similar items in EconPapers)
Date: 2024
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