Numerical Study on Dynamics of Blood Cell Migration and Deformation in Atherosclerotic Vessels

Yihao Wu, Hui Xing, Qingyu Zhang and Dongke Sun
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Yihao Wu: School of Mechanical Engineering, Southeast University, Nanjing 211189, China
Hui Xing: MOE Key Laboratory of Material Physics and Chemistry under Extraordinary, Shaanxi Key Laboratory for Condensed Matter Structure and Properties, Northwestern Polytechnical University, Xi’an 710129, China
Qingyu Zhang: High-Performance Metal Structural Materials Research Institute, School of Iron and Steel, Soochow University, Suzhou 215137, China
Dongke Sun: School of Mechanical Engineering, Southeast University, Nanjing 211189, China

Mathematics, 2022, vol. 10, issue 12, 1-13

Abstract: A phase field model is used to study the effect of atherosclerotic plaque on hemodynamics. The migration of cells in blood flows is described by a set of multiple phase field equations, which incorporate elastic energies and the interacting effects of cells. Several simulations are carried out to reveal the influences of initial velocities of blood cells, cellular elasticity and block rates of hemodynamic vessels. The results show that the cell deformation increases with the growth of the initial active velocity and block rate but with the decrease of the cellular elasticity. The atherosclerotic plaque not only affects the deformation and migration of cells but also can promote the variation in hemodynamic properties. The atherosclerotic plaque causes a burst in cell velocity, and the greater the block rate and cellular elasticity, the more dramatic the variation of instantaneous velocity. The present work demonstrates that the phase field method could be extended to reveal formation atherosclerosis at the microscopic level from the perspective of hemodynamics.

Keywords: phase field; cell migration; cell deformation; hemodynamics; atherosclerosis (search for similar items in EconPapers)
JEL-codes: C (search for similar items in EconPapers)
Date: 2022
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