Mathematical Model of Pancreatic Cancer Cell Dynamics Considering the Set of Sequential Mutations and Interaction with the Immune System

Alexander S. Bratus (), Nicholas Leslie, Michail Chamo, Dmitry Grebennikov, Rostislav Savinkov, Gennady Bocharov and Daniil Yurchenko
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Alexander S. Bratus: Institute of Management and Digital Technologies, Russian University of Transport, 127055 Moscow, Russia
Nicholas Leslie: School of Engineering & Physical Sciences, Heriot-Watt University, Edinburgh EH14 4AS, UK
Michail Chamo: Institute of Management and Digital Technologies, Russian University of Transport, 127055 Moscow, Russia
Dmitry Grebennikov: Marchuk Institute of Numerical Mathematics, Russian Academy of Sciences (INM RAS), 119333 Moscow, Russia
Rostislav Savinkov: Marchuk Institute of Numerical Mathematics, Russian Academy of Sciences (INM RAS), 119333 Moscow, Russia
Gennady Bocharov: Marchuk Institute of Numerical Mathematics, Russian Academy of Sciences (INM RAS), 119333 Moscow, Russia
Daniil Yurchenko: Institute for Sound and Vibration Research, University of Southampton, Highfield, Southampton SO17 1BJ, UK

Mathematics, 2022, vol. 10, issue 19, 1-12

Abstract: Pancreatic cancer represents one of the difficult problems of contemporary medicine. The development of the illness evolves very slowly, happens in a specific place (stroma), and manifests clinically close to a final stage. Another feature of this pathology is a coexistence (symbiotic) effect between cancer cells and normal cells inside stroma. All these aspects make it difficult to understand the pathogenesis of pancreatic cancer and develop a proper therapy. The emergence of pancreatic pre-cancer and cancer cells represents a branching stochastic process engaging populations of 64 cells differing in the number of acquired mutations. In this study, we formulate and calibrate the mathematical model of pancreatic cancer using the quasispecies framework. The mathematical model incorporates the mutation matrix, fineness landscape matrix, and the death rates. Each element of the mutation matrix presents the probability of appearing as a specific mutation in the branching sequence of cells representing the accumulation of mutations. The model incorporates the cancer cell elimination by effect CD8 T cells (CTL). The down-regulation of the effector function of CTLs and exhaustion are parameterized. The symbiotic effect of coexistence of normal and cancer cells is considered. The computational predictions obtained with the model are consistent with empirical data. The modeling approach can be used to investigate other types of cancers and examine various treatment procedures.

Keywords: pancreatic cancer; cancer evolution; tumor microenvironment; mathematical model; open quasispecies model (search for similar items in EconPapers)
JEL-codes: C (search for similar items in EconPapers)
Date: 2022
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