Modeling the Interplay between HDV and HBV in Chronic HDV/HBV Patients

Adequate Mhlanga, Rami Zakh, Alexander Churkin, Vladimir Reinharz, Jeffrey S. Glenn, Ohad Etzion, Scott J. Cotler, Cihan Yurdaydin (), Danny Barash () and Harel Dahari ()
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Adequate Mhlanga: The Program for Experimental and Theoretical Modeling, Division of Hepatology, Department of Medicine, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 84101, USA
Rami Zakh: Department of Computer Science, Ben-Gurion University, Beer-Sheva 84105, Israel
Alexander Churkin: Department of Software Engineering, Sami Shamoon College of Engineering, Beer-Sheva 84108, Israel
Vladimir Reinharz: Department of Computer Science, Université du Québec à Montréal, Montréal, QC H3C 3P8, Canada
Jeffrey S. Glenn: Division of Gastroenterology and Hepatology, Departments of Medicine, Microbiology & Immunology, Stanford School of Medicine, Stanford, CA 94305, USA
Ohad Etzion: Department of Gastroenterology and Liver Diseases, Soroka University Medical Center, Beer-Sheva 84101, Israel
Scott J. Cotler: The Program for Experimental and Theoretical Modeling, Division of Hepatology, Department of Medicine, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 84101, USA
Cihan Yurdaydin: Department of Gastroenterology and Hepatology, Koç University Medical School, Istanbul 34450, Turkey
Danny Barash: Department of Computer Science, Ben-Gurion University, Beer-Sheva 84105, Israel
Harel Dahari: The Program for Experimental and Theoretical Modeling, Division of Hepatology, Department of Medicine, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 84101, USA

Mathematics, 2022, vol. 10, issue 20, 1-13

Abstract: Hepatitis D virus is an infectious subviral agent that can only propagate in people infected with hepatitis B virus. In this study, we modified and further developed a recent model for early hepatitis D virus and hepatitis B virus kinetics to better reproduce hepatitis D virus and hepatitis B virus kinetics measured in infected patients during anti-hepatitis D virus treatment. The analytical solutions were provided to highlight the new features of the modified model. The improved model offered significantly better prospects for modeling hepatitis D virus and hepatitis B virus interactions.

Keywords: hepatitis delta virus; hepatitis B virus; anti-HDV treatment; analytical solution (search for similar items in EconPapers)
JEL-codes: C (search for similar items in EconPapers)
Date: 2022
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