Detecting Depression Using Single-Channel EEG and Graph Methods

Guohun Zhu (), Tong Qiu, Yi Ding, Shang Gao, Nan Zhao, Feng Liu, Xujuan Zhou and Raj Gururajan
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Guohun Zhu: School of Information Technology and Electrical Engineering, The University of Queensland, Brisbane 4072, Australia
Tong Qiu: School of Information Technology and Electrical Engineering, The University of Queensland, Brisbane 4072, Australia
Yi Ding: School of Information Technology and Electrical Engineering, The University of Queensland, Brisbane 4072, Australia
Shang Gao: School of Information Technology and Electrical Engineering, The University of Queensland, Brisbane 4072, Australia
Nan Zhao: School of Information Technology and Electrical Engineering, The University of Queensland, Brisbane 4072, Australia
Feng Liu: School of Information Technology and Electrical Engineering, The University of Queensland, Brisbane 4072, Australia
Xujuan Zhou: School of Business, The University of Southern Queensland, Toowoomba 4350, Australia
Raj Gururajan: School of Business, The University of Southern Queensland, Toowoomba 4350, Australia

Mathematics, 2022, vol. 10, issue 22, 1-9

Abstract: Objective: This paper applies graph methods to distinguish major depression disorder (MDD) and healthy (H) subjects using the graph features of single-channel electroencephalogram (EEG) signals. Methods: Four network features—graph entropy, mean degree, degree two, and degree three—were extracted from the 19-channel EEG signals of 64 subjects (26 females and 38 males), and then these features were forwarded to a support vector machine to conduct depression classification based on the eyes-open and eyes-closed statuses, respectively. Results: Statistical analysis showed that graph features with degree of two and three, the graph entropy of MDD was significantly lower than that for H ( p < 0.0001). Additionally, the accuracy of detecting MDD using single-channel T4 EEG with leave-one-out cross-validation from H was 89.2% and 92.0% for the eyes-open and eyes-closed statuses, respectively. Conclusion: This study shows that the graph features of a short-term EEG can help assess and evaluate MDD. Thus, single-channel EEG signals can be used to detect depression in subjects. Significance: Graph feature analysis discovered that MDD is more related to the temporal lobe than the frontal lobe.

Keywords: mental health; classification; isolate nodes; graph entropy; mean degree (search for similar items in EconPapers)
JEL-codes: C (search for similar items in EconPapers)
Date: 2022
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