Adsorption of Cisplatin Molecules in Nanoporous Inorganic Materials as Drug Delivery Vehicles

Mansoor H. Alshehri
Additional contact information
Mansoor H. Alshehri: Department of Mathematics, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia

Mathematics, 2022, vol. 10, issue 7, 1-9

Abstract: The use of nanoparticles as anticancer cargo systems for drug delivery is a promising modality, as they avoid the known toxicity of anticancer drugs on healthy cells by the delivery of multiple drugs to the target cells. Here, the adsorption behavior of cisplatin drug molecules in two different inorganic materials, silica and metallic gold, is investigated mathematically. The 6–12 Lennard-Jones potential, together with the continuum approximation, is adapted to calculate the molecular interatomic energies between molecules. For each material, the relation between the pore radius ℓ and the minimum energy is determined, and the results indicate that the minimum energy occurs when the radii are ℓ = 5.3 and ℓ = 4.7 Å for the silica and gold nanopores, respectively. The method is promising for applications in the design of novel nanocapsules for future targeted drug and gene delivery.

Keywords: mathematical modeling; cisplatin molecule; continuum approximation; inorganic materials; drug delivery; Lennard-Jones potential (search for similar items in EconPapers)
JEL-codes: C (search for similar items in EconPapers)
Date: 2022
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.mdpi.com/2227-7390/10/7/1018/pdf (application/pdf)
https://www.mdpi.com/2227-7390/10/7/1018/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:gam:jmathe:v:10:y:2022:i:7:p:1018-:d:776792

Access Statistics for this article

Mathematics is currently edited by Ms. Emma He

More articles in Mathematics from MDPI
Bibliographic data for series maintained by MDPI Indexing Manager ().