Advanced Analysis of Electrodermal Activity Measures to Detect the Onset of ON State in Parkinson’s Disease

Mercedes Barrachina-Fernández, Laura Valenzuela-López, Marcos Moreno-Verdú, Francisco José Sánchez-Cuesta, Yeray González-Zamorano, Juan Pablo Romero () and Carmen Sánchez-Ávila
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Mercedes Barrachina-Fernández: Programa en Ingeniería Biomédica, ETSI Telecomunicación, Polytechnic University of Madrid (UPM), Avenida Complutense, 30, 28040 Madrid, Spain
Laura Valenzuela-López: Brain Injury and Movement Disorders Neurorehabilitation Group (GINDAT), Institute of Life Sciences, Francisco de Vitoria University, 28223 Pozuelo de Alarcón, Spain
Marcos Moreno-Verdú: Brain Injury and Movement Disorders Neurorehabilitation Group (GINDAT), Institute of Life Sciences, Francisco de Vitoria University, 28223 Pozuelo de Alarcón, Spain
Francisco José Sánchez-Cuesta: Brain Injury and Movement Disorders Neurorehabilitation Group (GINDAT), Institute of Life Sciences, Francisco de Vitoria University, 28223 Pozuelo de Alarcón, Spain
Yeray González-Zamorano: Brain Injury and Movement Disorders Neurorehabilitation Group (GINDAT), Institute of Life Sciences, Francisco de Vitoria University, 28223 Pozuelo de Alarcón, Spain
Juan Pablo Romero: Brain Injury and Movement Disorders Neurorehabilitation Group (GINDAT), Institute of Life Sciences, Francisco de Vitoria University, 28223 Pozuelo de Alarcón, Spain
Carmen Sánchez-Ávila: Department Applied Mathematics, ETSI Telecomunicación, Polytechnic University of Madrid (UPM), 28040 Madrid, Spain

Mathematics, 2023, vol. 11, issue 23, 1-14

Abstract: Background: Electrodermal activity (EDA) serves as a prominent biosignal for assessing sympathetic activation across various scenarios. Prior research has suggested a connection between EDA and fluctuations in Parkinson’s disease (PD), but its precise utility in reliably detecting these fluctuations has remained unexplored. This study aims to evaluate the efficacy of both basic and advanced analyses of EDA changes in identifying the transition to the ON state following dopaminergic medication administration in individuals with PD. Methods: In this observational study, 19 individuals with PD were enrolled. EDA was continuously recorded using the Empatica E4 device, worn on the wrist, during the transition from the OFF state to the ON state following levodopa intake. The raw EDA signal underwent preprocessing and evaluation through three distinct approaches. A logistic regression model was constructed to assess the significance of variables predicting the ON/OFF state, and support vector machine (SVM) models along with various Neural Network (NN) configurations were developed for accurate state prediction. Results: Differences were identified between the ON and OFF states in both the time and frequency domains, as well as through the utilization of convex optimization techniques. SVM and NN models demonstrated highly promising results in effectively distinguishing between the OFF and ON states. Conclusions: Evaluating sympathetic activation changes via EDA measures holds substantial promise for detecting non-motor fluctuations in PD. The SVM algorithm, in particular, yields precise outcomes for predicting these non-motor fluctuation states.

Keywords: electrodermal activity; Parkinson; machine learning (search for similar items in EconPapers)
JEL-codes: C (search for similar items in EconPapers)
Date: 2023
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